PRIMA1

PRIMA1
Identifiers
AliasesPRIMA1, PRIMA, proline rich membrane anchor 1
External IDsOMIM: 613851; MGI: 1926097; HomoloGene: 15783; GeneCards: PRIMA1; OMA:PRIMA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178004
NM_178013

NM_133364
NM_178023

RefSeq (protein)

NP_821092
NP_821092.1

NP_579942

Location (UCSC)n/aChr 12: 103.16 – 103.21 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[4][5]

Function

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PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[4] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[6] The PRAD interacts with the C-terminal T-peptide of AChE.[7]

PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[5] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.

Clinical significance

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The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[8]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041669Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: proline rich membrane anchor 1".
  5. ^ a b Perrier AL, Massoulié J, Krejci E (Jan 2002). "PRiMA: the membrane anchor of acetylcholinesterase in the brain". Neuron. 33 (2): 275–85. doi:10.1016/S0896-6273(01)00584-0. PMID 11804574.
  6. ^ Xie HQ, Siow NL, Peng HB, Massoulié J, Tsim KW (Dec 2005). "Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle". Chemico-Biological Interactions. 157–158: 432. Bibcode:2005CBI...157..432X. doi:10.1016/j.cbi.2005.10.093. PMID 16429581.
  7. ^ Perrier NA, Khérif S, Perrier AL, Dumas S, Mallet J, Massoulié J (Oct 2003). "Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase". The European Journal of Neuroscience. 18 (7): 1837–47. doi:10.1046/j.1460-9568.2003.02914.x. PMID 14622217. S2CID 21808922.
  8. ^ Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (Sep 1983). "Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form". Neuroscience Letters. 40 (2): 199–204. doi:10.1016/0304-3940(83)90302-6. PMID 6633975. S2CID 45149066.

Further reading

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