40S ribosomal protein S10

RPS10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS10, DBA9, S10, ribosomal protein S10
External IDsOMIM: 603632; MGI: 1914347; HomoloGene: 788; GeneCards: RPS10; OMA:RPS10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204091
NM_001014
NM_001203245

NM_025963
NM_001364934

RefSeq (protein)

NP_001005
NP_001190174
NP_001191020

NP_080239
NP_001351863

Location (UCSC)Chr 6: 34.42 – 34.43 MbChr 17: 27.85 – 27.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.[5][6][7]

Function

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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

Clinical significance

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Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.[7] Mutations in the RPS10 gene can cause Diamond–Blackfan anemia, a congenital anemia sometimes associated with bone marrow failure.[8]

Interactions

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RPS10 has been shown to interact with PTTG1.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124614Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052146Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b c "Entrez Gene: RPS10 ribosomal protein S10".
  8. ^ Doherty, L; Sheen, MR; Vlachos, A; Choesmel, V; O'Donohue, MF; Clinton, C; Schneider, HE; Sieff, CA; Newburger, PE; Ball, SE; Niewiadomska, E; Matysiak, M; Glader, B; Arceci, RJ; Farrar, JE; Atsidaftos, E; Lipton, JM; Gleizes, PE; Gazda (Feb 2010). "Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond–Blackfan anemia. HT". Am J Hum Genet. 86 (2): 222–8. doi:10.1016/j.ajhg.2009.12.015. PMC 2820177. PMID 20116044.
  9. ^ Pei, L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. ISSN 0021-9258. PMID 9915854.

Further reading

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