Protein-coding gene in the species Homo sapiens
Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene .[ 5] [ 6] [ 7]
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.[ 7]
SNAP29 has been shown to interact with Syntaxin 3 [ 5] EHD1 .[ 8]
SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.[ 9] [ 10]
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Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Overview of all the structural information available in the PDB for UniProt : O95721 PDBe-KB .
