Protein-coding gene in the species Homo sapiens
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene .[ 5] [ 6]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[ 6]
SNX4 has been shown to interact with BIN1 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors" . Mol Cell Biol . 18 (12): 7278–87. doi :10.1128/mcb.18.12.7278 . PMC 109309 PMID 9819414 . ^ a b "Entrez Gene: SNX4 sorting nexin 4" .^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking" . J. Cell Sci . 116 (Pt 10). England: 1937–48. doi :10.1242/jcs.00403 ISSN 0021-9533 . PMID 12668730 . Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment". Nat. Cell Biol . 9 (12): 1370–80. doi :10.1038/ncb1656 . PMID 17994011 . S2CID 23816176 . Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic . 8 (3): 297–309. doi :10.1111/j.1600-0854.2006.00527.x . hdl :10852/11339 PMID 17319803 . S2CID 21600584 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking" . J. Cell Sci . 116 (Pt 10): 1937–48. doi :10.1242/jcs.00403 PMID 12668730 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases" . J. Biol. Chem . 276 (22): 19332–9. doi :10.1074/jbc.M100606200 PMID 11279102 .
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