SPINT2

SPINT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPINT2, DIAR3, HAI-2, HAI2, Kop, PB, serine peptidase inhibitor, Kunitz type, 2, serine peptidase inhibitor, Kunitz type 2
External IDsOMIM: 605124; MGI: 1338031; HomoloGene: 7955; GeneCards: SPINT2; OMA:SPINT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021102
NM_001166103

NM_001082548
NM_011464

RefSeq (protein)

NP_001159575
NP_066925

NP_001076017
NP_035594

Location (UCSC)Chr 19: 38.24 – 38.29 MbChr 7: 28.96 – 28.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.[5][6][7] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167642Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074227Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (May 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry. 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294.
  6. ^ Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Oct 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.
  7. ^ "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: O43291 (Kunitz-type protease inhibitor 2) at the PDBe-KB.