Protein-coding gene in the species Homo sapiens
Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene .[ 5] [ 6]
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[ 6]
TTF2 has been shown to interact with CDC5L .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000116830 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033222 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member" . The Journal of Biological Chemistry . 273 (40): 25541–4. doi :10.1074/jbc.273.40.25541 PMID 9748214 . ^ a b "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II" .^ Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 doi :10.1016/S0006-291X(03)01486-4 . PMID 12927788 . Girdham CH, Glover DM (October 1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein" . Genes & Development . 5 (10): 1786–99. doi :10.1101/gad.5.10.1786 PMID 1916263 . Hara R, Selby CP, Liu M, Price DH, Sancar A (August 1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer" . The Journal of Biological Chemistry . 274 (35): 24779–86. doi :10.1074/jbc.274.35.24779 PMID 10455150 . Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 doi :10.1016/S0006-291X(03)01486-4 . PMID 12927788 . Jiang Y, Liu M, Spencer CA, Price DH (May 2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation" . Molecular Cell . 14 (3): 375–85. doi :10.1016/S1097-2765(04)00234-5 PMID 15125840 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Jiang Y, Price DH (September 2004). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector" . Cell Cycle . 3 (9): 1151–3. doi :10.4161/cc.3.9.1151 PMID 15467445 .
