VUF-6002
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| Formula | C13H15ClN4O |
| Molar mass | 278.74 g·mol−1 |
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VUF-6002 (JNJ-10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has anti-inflammatory and analgesic effects in animal studies of inflammatory diseases.[2]
See also
[edit]- JNJ-7777120 (same molecule but where one nitrogen has been exchanged for a carbon)
References
[edit]- ^ Zhang M, Thurmond RL, Dunford PJ (March 2007). "The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders". Pharmacology & Therapeutics. 113 (3): 594–606. doi:10.1016/j.pharmthera.2006.11.008. PMID 17275092.
- ^ Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R (June 2007). "Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation". European Journal of Pharmacology. 563 (1–3): 240–4. doi:10.1016/j.ejphar.2007.02.026. PMID 17382315.
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