Heme oxygenase (decycling) 1 血红素加氧酶1(脱环) |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/5/56/Protein_HMOX1_PDB_1n3u.png/250px-Protein_HMOX1_PDB_1n3u.png) PDB rendering based on 1n3u. |
有效结构 | PDB | 直系同源检索:PDBe, RCSB | PDB查询代码列表 | 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM | | |
标识 |
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代号 | HMOX1; HMOX1D; HO-1; HSP32; bK286B10 |
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扩展标识 | 遗传学:141250 鼠基因:96163 同源基因:31075 ChEMBL: 2823 GeneCards: HMOX1 Gene |
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EC編號 | 1.14.99.3 |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/92/PBB_GE_HMOX1_203665_at_tn.png/250px-PBB_GE_HMOX1_203665_at_tn.png) |
更多表达数据 |
直系同源体 |
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物种 | 人类 | 小鼠 |
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Entrez | 3162 | 15368 |
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Ensembl | ENSG00000100292 | ENSMUSG00000005413 |
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UniProt | P09601 | P14901 |
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mRNA序列 | NM_002133 | NM_010442 |
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蛋白序列 | NP_002124 | NP_034572 |
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基因位置 | Chr 22: 35.78 – 35.79 Mb | Chr 8: 75.09 – 75.1 Mb |
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PubMed查询 | [1] | [2] |
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血红素加氧酶1(英語:heme oxygenase 1,缩写HMOX1或HO-1)是一种血红素加氧酶(EC 1.14.99.3),是血红素代谢过程中的重要酶,它将血红素转化为胆绿素。
- Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858
. PMID 9884342. doi:10.1172/JCI4165. - Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147
. PMID 17525142. doi:10.1093/brain/awm095. - Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x.
- Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862.
- Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x.
- Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767.
- Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008.
- Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630.
- Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894.
- Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093.