CLCA4

CLCA4
Identifiers
Aliases	CLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDs	OMIM: 616857; MGI: 2139744; HomoloGene: 40808; GeneCards: CLCA4; OMA:CLCA4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,580,754 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,680,806 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; oral cavity; ; mucosa of pharynx; ; rectum; ; mucosa of transverse colon; ; cervix epithelium; ; mucosa of urinary bladder; ; mucosa of ileum; ; nasal epithelium;
	Top expressed in
	jejunum; ; Paneth cell; ; left colon; ; ileum; ; duodenum; ; conjunctival fornix; ; lumbar subsegment of spinal cord; ; cornea; ; ciliary body; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; chloride channel activity; metalloendopeptidase activity; intracellular calcium activated chloride channel activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane;
Biological process	ion transmembrane transport; chloride transport; proteolysis; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	22802
	99663
	ENSG00000016602
	ENSMUSG00000068547
	Q14CN2
	Q6Q473
	NM_012128
	NM_207208
	NP_036260
	NP_997091
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.^[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

External links

CLCA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLCA4 genome location and CLCA4 gene details page in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10437792-5] Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.

[pmid16470849-6] Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

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CLCA4

See also

References

Further reading

External links

CLCA4

See also

References

Further reading

External links

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