PCTK1

CDK16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTL
Identifiers
Aliases	CDK16, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1, cyclin-dependent kinase 16, cyclin dependent kinase 16
External IDs	OMIM: 311550; MGI: 97516; HomoloGene: 7878; GeneCards: CDK16; OMA:CDK16 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	47,229,997 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,566,119 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; muscle of thigh; ; apex of heart; ; gastrocnemius muscle; ; right frontal lobe; ; ganglionic eminence; ; stromal cell of endometrium; ; right auricle; ; prefrontal cortex; ; ventricular zone;
	Top expressed in
	fossa; ; condyle; ; Paneth cell; ; motor neuron; ; ascending aorta; ; aortic valve; ; substantia nigra; ; lobe of cerebellum; ; cerebellar vermis; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; protein kinase activity; kinase activity; ATP binding; transferase activity; protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	microtubule cytoskeleton; synapse; cell junction; membrane; transport vesicle; cytoplasmic vesicle; neuron projection; extrinsic component of cytoplasmic side of plasma membrane; cytoplasm; plasma membrane; nucleus; cytosol; synaptic vesicle;
Biological process	phosphorylation; cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; protein phosphorylation; growth hormone secretion; spermatogenesis; exocytosis; neuron projection development; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5127
	18555
	ENSG00000102225
	ENSMUSG00000031065
	Q00536
	Q04735
	NM_001170460; NM_006201; NM_033018; NM_033019
	NM_011049; NM_001310456
	NP_001163931; NP_006192; NP_148978
	NP_001297385; NP_035179
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the CDK16 gene.^[5]^[6]

Function

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.^[6]

Interactions

PCTK1 has been shown to interact with CDK5R1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102225 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031065 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.
^ ^a ^b "Entrez Gene: PCTK1 PCTAIRE protein kinase 1".
^ Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
Knight JC, Renwick PJ, Downing JR, Okuda T (1995). "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3". Cytogenet. Cell Genet. 71 (2): 155–7. doi:10.1159/000134097. PMID 7656587.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, Willard HF (1996). "X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse". Hum. Mol. Genet. 5 (3): 391–401. doi:10.1093/hmg/5.3.391. PMID 8852665.
Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F (1997). "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins". Mol. Gen. Genet. 254 (5): 571–7. doi:10.1007/s004380050453. PMID 9197417. S2CID 22809140.
Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R, D'Urso M, Forabosco A (1997). "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E". Genomics. 43 (2): 183–90. doi:10.1006/geno.1997.4797. PMID 9244435.
Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. doi:10.1074/jbc.273.39.25388. PMID 9738006.
Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F (1998). "Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins". Eur. J. Biochem. 257 (1): 112–20. doi:10.1046/j.1432-1327.1998.2570112.x. PMID 9799109.
Besset V, Rhee K, Wolgemuth DJ (1999). "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation". Cell Growth Differ. 10 (3): 173–81. PMID 10099831.
Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.
Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T (2002). "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells" (PDF). J. Cell Sci. 115 (Pt 17): 3479–90. doi:10.1242/jcs.115.17.3479. PMID 12154078.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F (2004). "Protein profile of tax-associated complexes". J. Biol. Chem. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Liu Y, Cheng K, Gong K, Fu AK, Ip NY (2006). "Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis". J. Biol. Chem. 281 (15): 9852–8. doi:10.1074/jbc.M513496200. PMID 16461345.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102225 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031065 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1437147-5] Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.

[entrez-6] "Entrez Gene: PCTK1 PCTAIRE protein kinase 1".

[pmid12084709-7] Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PCTK1

Function

Interactions

References

Further reading

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