9-Phenanthrol
From Wikipedia the free encyclopedia
 | |
| Names | |
|---|---|
| IUPAC name 9-Phenanthrol | |
| Systematic IUPAC name 9-Hydroxyphenanthrene | |
Other names
| |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.006.912 |
| EC Number |
|
| KEGG | |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
| |
| |
| Properties | |
| C14H10O | |
| Molar mass | 194.233 g·mol−1 |
| Hazards | |
| GHS labelling: | |
 | |
| Warning | |
| H315, H319, H335 | |
| P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
9-Phenanthrol is an aromatic alcohol derived from phenanthrene, a tricyclic compound. It is a TRPM4 channel inhibitor.[1] It can prevent the pancreas from secreting insulin when stimulated by glucose.[2]
References[edit]
- ^ Guinamard, R; Hof, T; Del Negro, C A (2014). "The TRPM4 channel inhibitor 9-phenanthrol". British Journal of Pharmacology. 171 (7): 1600–1613. doi:10.1111/bph.12582. PMC 3966741. PMID 24433510.
- ^ Ma, Zuheng; Björklund, Anneli; Islam, Md. Shahidul (2017). "A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans". Journal of Diabetes Research. 2017: 1–5. doi:10.1155/2017/5131785. PMC 5643033. PMID 29098165.