ANP32E

ANP32E
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4CAY, 4NFT
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611 HomoloGene: 137403 GeneCards: ANP32E
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,236,156 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; caput epididymis; ; corpus epididymis; ; retinal pigment epithelium; ; optic nerve; ; germinal epithelium; ; ganglionic eminence; ; superficial temporal artery; ; sural nerve; ; bone marrow;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone binding; phosphatase inhibitor activity;
Cellular component	cytoplasm; nucleus; Swr1 complex; cytoplasmic vesicle;
Biological process	negative regulation of catalytic activity; histone exchange; nucleosome assembly; nucleocytoplasmic transport; regulation of apoptotic process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	81611
	n/a
	ENSG00000143401
	n/a
	Q9BTT0
	n/a
	NM_001136478; NM_001136479; NM_001280559; NM_001280560; NM_030920
	n/a
	NP_001129950; NP_001129951; NP_001267488; NP_001267489; NP_112182
	n/a
	Wikidata
View/Edit Human

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^[3]^[4] The ANP32E gene is located on chromosome 1q22.^[3] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[5] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[6] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.
^ "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
^ Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.
^ Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.
^ Santa-Coloma, T.A. (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

External links[edit]

Human ANP32E genome location and ANP32E gene details page in the UCSC Genome Browser.

Further reading[edit]

Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553. S2CID 39153579.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Radrizzani, M.; Vilá-Ortiz, G.; Cafferata, E. G.; Di Tella, M. C.; González-Guerrico, A.; Perandones, C.; Pivetta, O. H.; Carminatti, H.; Idoyaga Vargas, V. P.; Santa-Coloma, T. A. (2001). "Differential expression of CPD1 during postnatal development in the mouse cerebellum". Brain Research. 907 (1–2): 162–174. doi:10.1016/s0006-8993(01)02351-4. PMID 11430900. S2CID 29698240.
Radrizzani, M.; Brocardo, M. G.; Gonzalez Solveyra, C.; Bianchini, M.; Reyes, G. B.; Cafferata, E. G.; Vilá Ortiz, G.; Santa-Coloma, T. A. (2000). "Development of monoclonal oligobodies and chemically synthesized oligobodies". Medicina. 60 (Suppl 2): 55–60. PMID 11188933.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143401 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12438741-3] Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.

[entrez-4] "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".

[pmid24463511-5] Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.

[pmid16420440-6] Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.

[pmid14964690-7] Santa-Coloma, T.A. (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

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ANP32E

See also[edit]

References[edit]

External links[edit]

Further reading[edit]

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