Protein-coding gene in the species Homo sapiens
ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene .[5] [6]
Function [ edit ] The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF ) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68 ) that is overexpressed in some tumors.[6]
Interactions [ edit ] ARFRP1 has been shown to interact with PSCD1 .[7]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000101246 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038671 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors" . J Biol Chem . 270 (51): 30657–63. doi :10.1074/jbc.270.51.30657 PMID 8530503 . ^ a b "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1" .^ Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D" . J. Biol. Chem . 274 (14): 9744–51. doi :10.1074/jbc.274.14.9744 PMID 10092663 . Further reading [ edit ] Zahn C, Hommel A, Lu L, et al. (2007). "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells". Mol. Membr. Biol . 23 (6): 475–85. doi :10.1080/09687860600840100 . PMID 17127620 . S2CID 22778359 . Shin HW, Kobayashi H, Kitamura M, et al. (2005). "Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking" . J. Cell Sci . 118 (Pt 17): 4039–48. doi :10.1242/jcs.02524 PMID 16129887 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Behnia R, Panic B, Whyte JR, Munro S (2004). "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p". Nat. Cell Biol . 6 (5): 405–13. doi :10.1038/ncb1120 . PMID 15077113 . S2CID 22954283 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Coppola T, Magnin-Luthi S, Perret-Menoud V, et al. (2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin" . J. Biol. Chem . 276 (35): 32756–62. doi :10.1074/jbc.M100929200 PMID 11438518 . Bai C, Connolly B, Metzker ML, et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster" . Proc. Natl. Acad. Sci. U.S.A . 97 (3): 1230–5. Bibcode :2000PNAS...97.1230B . doi :10.1073/pnas.97.3.1230 PMC 15578 PMID 10655513 . Schürmann A, Schmidt M, Asmus M, et al. (1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D." J. Biol. Chem . 274 (14): 9744–51. doi :10.1074/jbc.274.14.9744 PMID 10092663 . External links [ edit ]
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