CSN1S1

CSN1S1
Identifiers
Aliases	CSN1S1, CASA, CSN1, casein alpha s1
External IDs	OMIM: 115450; HomoloGene: 48054; GeneCards: CSN1S1; OMA:CSN1S1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	69,946,574 bp
RNA expression pattern
	Top expressed in
	testicle; ; parotid gland; ; synovial membrane; ; gonad; ; synovial joint; ; adipose tissue; ; subcutaneous adipose tissue; ; lactiferous gland; ; cingulate gyrus; ; anterior cingulate cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity;
Cellular component	extracellular region; extracellular space;
Biological process	transmembrane transport; transport; response to estradiol; response to progesterone; response to dehydroepiandrosterone; response to 11-deoxycorticosterone;
	Sources:Amigo / QuickGO
Orthologs
	1446
	n/a
	ENSG00000126545
	n/a
	P47710
	n/a
	NM_001025104; NM_001890
	n/a
	NP_001020275; NP_001881
	n/a
	Wikidata
View/Edit Human

Alpha-S1-casein is a protein that in humans is encoded by the CSN1S1 gene.^[3]^[4]^[5]

Interactions

CSN1S1 has been shown to interact with SAP130.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126545 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.
^ Johnsen LB, Rasmussen LK, Petersen TE, Berglund L (Aug 1995). "Characterization of three types of human alpha s1-casein mRNA transcripts". Biochem J. 309. ( Pt 1) (Pt 1): 237–42. doi:10.1042/bj3090237. PMC 1135825. PMID 7619062.
^ "Entrez Gene: CSN1S1 casein alpha s1".
^ Menon, Suchithra; Tsuge Tomohiko; Dohmae Naoshi; Takio Koji; Wei Ning (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.

External links

Human CSN1S1 genome location and CSN1S1 gene details page in the UCSC Genome Browser.

Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain". FEBS Lett. 372 (1): 59–64. doi:10.1016/0014-5793(95)00955-9. PMID 7556643. S2CID 42295269.
Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. 270 (37): 21695–700. doi:10.1074/jbc.270.37.21695. PMID 7665586.
Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11→q25". Cytogenet. Cell Genet. 69 (3–4): 260–5. doi:10.1159/000133976. PMID 7698025.
Cavaletto M, Cantisani A, Giuffrida G, et al. (1994). "Human alpha S1-casein like protein: purification and N-terminal sequence determination". Biol. Chem. Hoppe-Seyler. 375 (2): 149–51. doi:10.1515/bchm3.1994.375.2.149. PMID 8192860.
Murakami K, Lagarde M, Yuki Y (1999). "Identification of minor proteins of human colostrum and mature milk by two-dimensional electrophoresis". Electrophoresis. 19 (14): 2521–7. doi:10.1002/elps.1150191427. PMID 9820977. S2CID 22786503.
Silljé HH, Takahashi K, Tanaka K, et al. (1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J. 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMC 1171636. PMID 10523312.
Menegay HJ, Myers MP, Moeslein FM, Landreth GE (2000). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell Sci. 113. ( Pt 18) (18): 3241–53. doi:10.1242/jcs.113.18.3241. PMID 10954422.
Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Kashiwaba M, Katsura K, Ohnishi M, et al. (2003). "A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9". FEBS Lett. 538 (1–3): 197–202. doi:10.1016/S0014-5793(03)00153-4. PMID 12633878. S2CID 32830511.
Xu K, Ling MT, Wang X, Wong YC (2007). "Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia". Prostate Cancer Prostatic Dis. 9 (3): 293–7. doi:10.1038/sj.pcan.4500872. PMID 16683014. S2CID 11411039.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126545 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9050925-3] Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.

[pmid7619062-4] Johnsen LB, Rasmussen LK, Petersen TE, Berglund L (Aug 1995). "Characterization of three types of human alpha s1-casein mRNA transcripts". Biochem J. 309. ( Pt 1) (Pt 1): 237–42. doi:10.1042/bj3090237. PMC 1135825. PMID 7619062.

[entrez-5] "Entrez Gene: CSN1S1 casein alpha s1".

[pmid18173839-6] Menon, Suchithra; Tsuge Tomohiko; Dohmae Naoshi; Takio Koji; Wei Ning (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.

[1]

[2]

[3]

[4]

[5]

[6]

CSN1S1

Interactions

References

External links

Further reading

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