Cefalotin
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a682860 |
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| Routes of administration | Intravenous |
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| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | 65 to 80% |
| Metabolism | Hepatic |
| Elimination half-life | 30 minutes to 1 hour |
| Excretion | Renal |
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| ECHA InfoCard | 100.005.288 |
| Chemical and physical data | |
| Formula | C16H16N2O6S2 |
| Molar mass | 396.43 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 160 to 160.5 °C (320.0 to 320.9 °F) |
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Cefalotin (INN) /ˌsɛfəˈloʊtɪn/ or cephalothin (USAN) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity.[1][2] It was the first cephalosporin marketed (1964) and continues to be widely used.[3] Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.[2]
It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agents cefalexin and cefadroxil. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.[4]
The compound is a derivative of thiophene-2-acetic acid.[5]
References
[edit]- ^ Hameed TK, Robinson JL (July 2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian Journal of Infectious Diseases. 13 (4): 253–8. doi:10.1155/2002/712594. PMC 2094874. PMID 18159398.
- ^ a b "Cefalotin - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024-01-26.
- ^ Greenwood D (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5.
- ^ International Drug Names: Cefalotin
- ^ Swanston, Jonathan (2006). "Thiophene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a26_793.pub2. ISBN 3527306730..
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