Christopher E. Mason

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Christopher E. Mason
Christopher E. Mason at the MAQC conference
April 2019
Alma materUniversity of Wisconsin–Madison (BA), Yale University (PhD)
Scientific career
FieldsBiology
InstitutionsWeill Cornell Medicine
Doctoral studentsLenore Pipes
Websitehttps://physiology.med.cornell.edu/people/christopher-mason-ph-d/

Christopher E. Mason is a professor of Genomics, Physiology, and Biophysics at Weill Cornell Medicine. He is also one of the founding Directors of the WorldQuant Initiative for Quantitative Prediction together with Olivier Elemento.[1] Mason has co-founded four biotechnology startup companies including Onegevity Health, Biotia, BridgeOmics, and Genome Liberty.[2][3][4]

Education[edit]

Mason completed his dual BS in genetics and biochemistry from the University of Wisconsin–Madison in 2001.[5] He did his PhD in genetics from Yale University in 2006.[6] He completed a post-doctoral fellowship in clinical genetics at Yale Medical School, while also serving as the first visiting fellow of genomics, ethics, and law at the Information Society Project at Yale Law School.[citation needed] Mason began work at Weill Cornell Medical College in 2009.[7][5][8][9]

Career[edit]

Human Spaceflight Research[edit]

Mason was a principal investigator for the NASA Twins Study.[10][11] He also led the first demonstration of sequencing in zero gravity and designed the genomics and bioinformatics methods and experimental protocols that were used on the International Space Station (ISS) for the mission to sequence DNA in space for the first time. The results looks promising for Mars mission.[12] This work also led to Mason's selection as the chair of the steering committee for the NASA GeneLab Data and Sample Archive (2018-2022) and has highlighted Weill Cornell Medicine on two NASA mission patches.[13] Mason also was selected by the National Academy of Sciences for the Decadal Survey for NASA.

Microbe Research[edit]

In 2013, Mason launched the PathoMap project to create the first genetic map of a city.[14][15] This study led to the establishment of the International MetaSUB Consortium.[16][17][18] Mason's group additionally elucidated the underlying microbial mechanisms for the pink color of Lake Hillier.[19][20]

Research Software[edit]

In addition to producing journal articles, Mason's laboratory has also released 12 open-source software packages in genomics, epigenomics, metagenomics, and machine learning (methylKit, r-make, MeRiPPeR, eDMR, methclone, mCaller, genomation, DISCO, UNFOG, CNVision, TWG Browser, Metagenscope).[21][22][23][non-primary source needed]

Bibliography[edit]

  • Mason, Christopher E. (2021). The Next 500 Years: Engineering Life to Reach New Worlds. MIT Press. ISBN 9780262360067.[24]
  • Tulchinsky, Igor; Mason, Christopher E. (2023). The Age of Prediction: Algorithms, AI, and Shifting Shadows of Risk. MIT Press. ISBN 9780262047739.

References[edit]

  1. ^ "Christopher E. Mason". Cornell Research. January 10, 2018. Retrieved June 11, 2020.
  2. ^ cosmeticsdesign.com. "Consumer intelligence company Onegevity Health plans expansion into skin care". cosmeticsdesign.com. Retrieved June 11, 2020.
  3. ^ nutraingredients-usa.com. "Healthcare is coming to the home, and companies should be prepared to offer vertical solutions, says Thorne CEO". nutraingredients-usa.com. Retrieved June 11, 2020.
  4. ^ Meydan, Cem; Afshinnekoo, Ebrahim; Rickard, Nate; Daniels, Guy; Kunces, Laura; Hardy, Theresa; Lili, Loukia; Pesce, Sarah; Jacobson, Paul; Mason, Christopher E.; Dudley, Joel (2020). "Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions". Precision Clinical Medicine. 3 (2): 136–146. doi:10.1093/pcmedi/pbaa013. PMC 7327130. PMID 32685241.
  5. ^ a b "Christopher E. Mason". Vivo. Weill Cornell Medical College. Retrieved June 11, 2020.
  6. ^ Mason, Christopher E. (2006). Genome evolution between Drosophila melanogaster and Drosophila pseudoobscura (PhD thesis). Yale University. ISBN 9780542995415. ProQuest 304979300
  7. ^ "Chris Mason on integrating art, law, and humanity through metagenomics of the earth and beyond". Genes to Genomes. January 24, 2018. Retrieved June 11, 2020.
  8. ^ "The Mason Lab". www.masonlab.net. Retrieved June 11, 2020.
  9. ^ Gould, Skye; Mosher, Dave (April 20, 2017). "Mars colonists will get blasted with radiation levels 8 times higher than government limits -- here's what they're up against". Business Insider Australia. Retrieved June 11, 2020.
  10. ^ Perez, Jason (April 14, 2015). "Twins Study". NASA. Retrieved June 11, 2020.
  11. ^ Mars, Kelli (February 1, 2018). "Meet the Researchers - Gene Expression". NASA. Retrieved June 11, 2020.
  12. ^ "NASA Twins Study Scientist: Results Look Promising for Mars Mission, But Many Questions Still Remain". Research & Development World. April 17, 2019. Retrieved June 11, 2020.
  13. ^ "Current VWG Members". NASA GeneLab. Retrieved June 11, 2020.
  14. ^ Harris, Elizabeth A. (November 11, 2013). "Among New York Subway's Millions of Riders, a Study Finds Many Mystery Microbes". The New York Times. Retrieved May 15, 2022.
  15. ^ Khamsi, Roxanne (November 11, 2013). "Subway Freeloaders". New York Magazine. Retrieved May 15, 2022.
  16. ^ O'Grady, Cathleen (May 26, 2021). "Cities have their own distinct microbial fingerprints". Science. Retrieved September 5, 2021.
  17. ^ "2017-09-microbiome". corporate.qiagen.com. Retrieved June 11, 2020.
  18. ^ "Big Data and Bacteria: Mapping the New York Subway's DNA | Sandra and Edward Meyer Cancer Center". meyercancer.weill.cornell.edu. Retrieved June 11, 2020.
  19. ^ "Red and purple microbes give Australia's mysterious pink lake its hue". www.newscientist.com/. Retrieved November 23, 2023.
  20. ^ Sierra, Maria A.; Ryon, Krista A.; Tierney, Braden T.; Foox, Jonathan; Bhattacharya, Chandrima; Afshin, Evan; Butler, Daniel; Green, Stefan J.; Thomas, W. Kelley; Ramsdell, Jordan; Bivens, Nathan J.; McGrath, Ken; Mason, Christopher E.; Tighe, Scott W. (December 21, 2022). "Microbiome and metagenomic analysis of Lake Hillier Australia reveals pigment-rich polyextremophiles and wide-ranging metabolic adaptations". Environmental Microbiome. 17 (1). doi:10.1186/s40793-022-00455-9. PMC 9768965.
  21. ^ Akalin, Altuna; Kormaksson, Matthias; Li, Sheng; Garrett-Bakelman, Francine E.; Figueroa, Maria E.; Melnick, Ari; Mason, Christopher E. (October 3, 2012). "methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles". Genome Biology. 13 (10): R87. doi:10.1186/gb-2012-13-10-r87. ISSN 1474-760X. PMC 3491415. PMID 23034086.
  22. ^ Li, Sheng; Garrett-Bakelman, Francine E; Akalin, Altuna; Zumbo, Paul; Levine, Ross; To, Bik L; Lewis, Ian D; Brown, Anna L; D'Andrea, Richard J; Melnick, Ari; Mason, Christopher E (April 10, 2013). "An optimized algorithm for detecting and annotating regional differential methylation". BMC Bioinformatics. 14 (Suppl 5): S10. doi:10.1186/1471-2105-14-S5-S10. ISSN 1471-2105. PMC 3622633. PMID 23735126.
  23. ^ Li, Sheng; Garrett-Bakelman, Francine; Perl, Alexander E; Luger, Selina M; Zhang, Chao; To, Bik L; Lewis, Ian D; Brown, Anna L; D'Andrea, Richard J; Ross, M Elizabeth; Levine, Ross (2014). "Dynamic evolution of clonal epialleles revealed by methclone". Genome Biology. 15 (9): 472. doi:10.1186/s13059-014-0472-5. ISSN 1465-6906. PMC 4242486. PMID 25260792.
  24. ^ Reviews of The Next 500 Years

External links[edit]

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