Eosinophilic ulcer of the oral mucosa
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| Eosinophilic ulcer of the oral mucosa | |
|---|---|
| Other names | Eosinophilic ulcer of the tongue,[1] Riga–Fede disease,[1] |
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| Eosinophilic ulcer of the oral mucosa – H&E stain | |
Eosinophilic ulcer of the oral mucosa (also known as traumatic eosinophilic granuloma[1]) is a condition characterized by an ulcer with an indurated and elevated border.[2] The lesion might be tender, fast-growing and the patient often not be aware of any trauma in the area.
Causes[edit]
It is often associated with trauma. However, other causes are suspected, such as drugs, inherent predisposition, immune reaction, or lymphoproliferative disorder.[citation needed]
Also called T.U.G.S.E.[3] Found in parasitic infections of the alimentary canal. Symptoms prior to onset of oral ulcers are; constipation, diarrhea, abdominal gas and bloating, spastic hiccups, acid reflux and heartburn. Burning mouth syndrome appears as pre-onset symptom of ulcer manifestation. Uncotrollable belching is a later symptom associated with a systemic parasitic infection with additional symptoms.[citation needed]
Diagnosis[edit]
Differential Diagnosis[edit]
Squamous Cell Carcinoma, Alimentary Parasitic Infection, Pyogenic granulomas, Lesions of a chronic granulomatous disease and Mesenchymal tumors
Definition[edit]
Traumatic eosinophilic granuloma of the tongue (TEGT) is a reactive condition in parasitic infections (which are not seen in pathological examination) that commonly occurs on the ventral tongue as well as the buccal mucosa.
Treatment[edit]
When the lesion is excised, recurrence often occurs. Palliative care with nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, and topical steroids can be curative. If the lesion does not respond to treatment, biopsy is required.
See also[edit]
References[edit]
- ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.[page needed]
- ^ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. p. 803. ISBN 978-0-7216-2921-6.
- ^ Chavan, Sateesh S.; Reddy, Purushotham (2013). "Traumatic ulcerative eosinophillic granuloma with stromal eosinophilia of tongue". South Asian Journal of Cancer. 2 (3): 144. doi:10.4103/2278-330X.114128. PMC 3892553. PMID 24455596.
Further reading[edit]
- Ficarra, G.; Prignano, F.; Romagnoli, P. (September 1997). "Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder?". Oral Oncology. 33 (5): 375–379. doi:10.1016/S1368-8375(97)00014-6. PMID 9415340.