Gregory Hannon

From Wikipedia the free encyclopedia

Greg Hannon
FRS FMedSci
Born
Gregory James Hannon[6]

1964 (age 59–60)[7]
Alma materCase Western Reserve University (BA, PhD)[8]
AwardsEMBO Member (2018)[1]
Royal Society Wolfson Research Merit Award (2015)[2]
Scientific career
Fields
InstitutionsUniversity of Cambridge
New York Genome Center
Cold Spring Harbor Laboratory
Howard Hughes Medical Institute[4]
ThesisTrans-splicing of nematode pre-messenger RNA (1992)
Doctoral advisorTimothy W. Nilsen[5]
Doctoral studentsEmily Bernstein
Other notable studentsLin He (postdoc), Camila dos Santos (postdoc)
Websitehannonlab.org

Gregory James Hannon FRS FMedSci[9] (born 1964) is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Institute at the University of Cambridge.[8] He is a Fellow of Trinity College, Cambridge[10][11] while also serving as a director of cancer genomics at the New York Genome Center[12] and an adjunct professor at Cold Spring Harbor Laboratory.[13]

Career and research

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Hannon is known for his contributions to small RNA biology, cancer biology, and mammalian genomics.[9][3][14][15] He has a history in discovery of oncogenes, beginning with work that led to the identification of CDK inhibitors and their links to cancer.[9] More recently, his work has focused on small RNA biology, which led to an understanding of the biochemical mechanisms and biological functions of RNA interference (RNAi).[16][17][9] He has developed widely used tools and strategies for manipulation of gene expression in mammalian cells and animals and has generated genome-wide short hairpin RNA (shRNA) libraries that are available to the cancer community and was among the first to demonstrate roles for microRNAs in cancer.[9][18] His laboratory also discovered the piwi-interacting RNA (piRNA) pathway and linked this to transposon repression and the protection of germ cell genomes.[9] His innovations include the development of selective re-sequencing strategies, broadly termed exome capture.[9]

In 2017, Hannon was awarded a £20 million Cancer Grand Challenges[19] award to unite the IMAXT team - a team of researchers from Switzerland, Ireland, Canada, the USA and the UK, with far ranging expertise from cancer biology and pathology to astronomy and even VR video game design. The team's aim is to create an interactive 3D map of cancer, which could be explored in virtual reality.[20][21] The programme could transform the way researchers study cancer by providing unprecedented insight into how individual cells are arranged and how they interact to allow the tumour to grow.[22][23]

In 2018, it was announced Prof Hannon would guide the Functional Genomics Centre, a collaboration between Cancer Research UK and AstraZeneca.[24] The centre, housed inside the Milner Therapeutics Institute, aims to act as a hub for genetic screens, cancer models, CRISPR tool design, and computational approaches to big data to understand genetic changes in cancer development and identify potential drug targets.[23][25]

Awards and honours

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References

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  1. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 20 June 2018.
  2. ^ "Gregory Hannon". royalsociety.org. Retrieved 20 June 2018.
  3. ^ a b c d e f Gregory Hannon publications indexed by Google Scholar Edit this at Wikidata
  4. ^ "Gregory J. Hannon, PhD - HHMI.org".
  5. ^ Hannon, Gregory James (1992). Trans-splicing of nematode pre-messenger RNA (PhD thesis). Case Western Reserve University. OCLC 29529734. ProQuest 304045738.
  6. ^ Greg Hannon's ORCID 0000-0003-4021-3898
  7. ^ Gregory Hannon at Library of Congress
  8. ^ a b "Greg Hannon – Hannon Laboratory". hannonlab.org. Retrieved 20 June 2018.
  9. ^ a b c d e f g Anon (2018). "Professor Gregory Hannon FRS". royalsociety.org. London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Terms, conditions and policies | Royal Society". Archived from the original on 2016-11-11. Retrieved 2018-06-20.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  10. ^ "Professor Greg Hannon leads £20 million Grand Challenge project to build 3D cancer tumour". 10 February 2017.
  11. ^ "Professor Greg Hannon appointed new Director of Cancer Research UK Cambridge Institute". 17 November 2017.
  12. ^ "Hannon Lab @ New York Genome Center". nygenome.org. Retrieved 20 June 2018.
  13. ^ "Hannon Laboratory @CSHL". hannonlab.cshl.edu.
  14. ^ Gregory Hannon publications indexed by the Scopus bibliographic database. (subscription required)
  15. ^ Gregory Hannon publications from Europe PubMed Central
  16. ^ Hannon, Gregory J. (2002). "RNA interference". Nature. 418 (6894): 244–251. Bibcode:2002Natur.418..244H. doi:10.1038/418244a. ISSN 0028-0836. PMID 12110901. S2CID 4426281. Closed access icon
  17. ^ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. Bibcode:2001Natur.409..363B. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481. Closed access icon
  18. ^ Murchison, Elizabeth P.; Hannon, Gregory J. (2004). "miRNAs on the move: miRNA biogenesis and the RNAi machinery". Current Opinion in Cell Biology. 16 (3): 223–9. doi:10.1016/j.ceb.2004.04.003. PMID 15145345. Closed access icon
  19. ^ cancergrandchallenges.org/teams/imaxt
  20. ^ Kaiser, Jocelyn (2017-02-09). "U.K. cancer charity awards £71 million for four major research challenges". Science | AAAS. Retrieved 2019-08-28.
  21. ^ "Cancer Research UK announces four 'Grand Challenge' teams". www.timeshighereducation.com. 10 February 2017. Retrieved 2019-08-28.
  22. ^ Walsh, Fergus (2018-12-26). "'Virtual tumour' new way to see cancer". Retrieved 2019-08-28.
  23. ^ a b Salter, Jessica (2019-07-29). "Researchers are using virtual reality in the fight against cancer". The Telegraph. ISSN 0307-1235. Retrieved 2019-08-28.
  24. ^ "Cancer Research UK and AstraZeneca launch world class functional genomics centre". Cancer Research UK. 2018-12-10. Retrieved 2019-08-28.
  25. ^ "AstraZeneca and CRUK launch Cambridge centre to accelerate cancer drug development". Cambridge Independent. 2018-12-10. Retrieved 2019-08-28.
  26. ^ "Gregory J. Hannon, Ph.D." pew.org. Retrieved 2019-08-28.
  27. ^ "Gregory J. Hannon". Rita Allen Foundation. August 10, 2016. Retrieved 2019-08-28.
  28. ^ "Press Release: Innovator Award Recipients from the DOD Breast Cancer Research Program; Congressionally Directed Medical Research Programs (CDMRP)". cdmrp.army.mil. Retrieved 2019-08-28.
  29. ^ "Greg Hannon awarded the 2005 AACR Award for Outstanding Achievement in Cancer Research". Cold Spring Harbor Laboratory. 2005-04-27. Retrieved 2019-08-28.
  30. ^ "AACR Award for Outstanding Achievement in Cancer Research". www.aacr.org. Archived from the original on 2019-08-28. Retrieved 2019-08-28.
  31. ^ "CSHL molecular biologist honored by National Academy of Sciences". Cold Spring Harbor Laboratory. 2007-01-17. Retrieved 2019-08-28.
  32. ^ "2007 Prize Winners". Memorial Sloan Kettering Cancer Center. Retrieved 2019-08-28.
  33. ^ "Paul Marks Prize Recognizes Three Young Cancer Researchers". Memorial Sloan Kettering Cancer Center. September 26, 2007. Retrieved 2019-08-28.
  34. ^ "CSHL Professor Gregory Hannon elected to U.S. National Academy of Sciences". Cold Spring Harbor Laboratory. 2012-05-01. Retrieved 2019-08-28.
  35. ^ "Gregory Hannon". www.nasonline.org. Retrieved 2019-08-28.
  36. ^ a b "Gregory Hannon | Royal Society". royalsociety.org. Retrieved 2019-08-28.
  37. ^ "Professor Gregory Hannon | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2019-08-28.
  38. ^ "The Academy of Medical Sciences announces new Fellows for 2017". University of Cambridge. 2017-05-08. Retrieved 2019-08-28.
  39. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2019-08-28.
  40. ^ "Prof Greg Hannon elected to EMBO Membership". Cancer Research UK Cambridge Institute. 2018-05-14. Retrieved 2019-08-28.
  41. ^ "Fellows| European Academy of Cancer Sciences". www.europeancanceracademy.eu. Archived from the original on 2019-07-04. Retrieved 2019-11-13.
  42. ^ "AACR Announces Fellows of the AACR Academy Class of 2020 | AACR | News Releases". American Association for Cancer Research (AACR). Retrieved 2020-06-05.

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