Protein-coding gene in the species Homo sapiens
Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene .[5] [6] [7] [8] metastasis suppressor .
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000109854 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039745 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Xiao H, Tao Y, Greenblatt J, Roeder RG (Apr 1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription" . Proc Natl Acad Sci U S A . 95 (5): 2146–51. Bibcode :1998PNAS...95.2146X . doi :10.1073/pnas.95.5.2146 PMC 19278 PMID 9482853 . ^ Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma" . Oncogene . 14 (18): 2167–73. doi :10.1038/sj.onc.1201059 PMID 9174052 . ^ ^ "Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa" . Further reading [ edit ] Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases" . Curr. Biol . 9 (13): R471. doi :10.1016/S0960-9822(99)80297-8 PMID 10395547 . S2CID 7740085 . Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis" . Mol. Cell. Biol . 20 (2): 583–93. doi :10.1128/MCB.20.2.583-593.2000 . PMC 85138 PMID 10611237 . Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes" . EMBO J . 19 (5): 956–63. doi :10.1093/emboj/19.5.956 . PMC 305635 PMID 10698937 . Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression" . Cell. Mol. Life Sci . 57 (5): 851–8. doi :10.1007/s000180050047 PMID 10892349 . S2CID 25141732 . NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro" . Oncogene . 20 (2): 270–5. doi :10.1038/sj.onc.1204075 PMID 11313954 . Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2004). "TIP30 deficiency increases susceptibility to tumorigenesis". Cancer Res . 63 (24): 8763–7. PMID 14695192 . Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription" . J. Biol. Chem . 279 (26): 27781–9. doi :10.1074/jbc.M401809200 PMID 15073177 . Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)" . Am. J. Hum. Genet . 74 (6): 1255–61. doi :10.1086/421527 . PMC 1182089 PMID 15124103 . King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3" . Mol. Cell. Biol . 24 (16): 7091–101. doi :10.1128/MCB.24.16.7091-7101.2004 . PMC 479715 PMID 15282309 . Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation". Annals of Biomedical Engineering . 32 (9): 1193–201. doi :10.1114/B:ABME.0000039353.97347.28 . PMID 15493507 . S2CID 31410967 . Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway" . World J. Gastroenterol . 11 (2): 221–7. doi :10.3748/wjg.v11.i2.221 PMC 4205406 PMID 15633220 . El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor" . J. Biol. Chem . 280 (18): 18229–36. doi :10.1074/jbc.M501113200 PMID 15728189 . Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription". Arch. Biochem. Biophys . 449 (1–2): 27–33. doi :10.1016/j.abb.2006.02.020 . PMID 16615932 .
PDB gallery
2bka : CC3(TIP30) crystal structure
2fmu : Crystal structure of Tat-interacting protein 30 kDa (HIV-1 tat interactive protein 2, 30 kDa homolog) (Human) (16924205) from Mus musculus at 2.30 A resolution
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