Jeffrey L. Saver

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Jeffrey L. Saver is an American neurologist who is the Carol and James Collins Distinguished Professor of Neurology at the David Geffen School of Medicine, University of California, Los Angeles.[1]

Early life and education[edit]

Saver received his A.B. degree at Harvard College (1981), where he studied biochemical sciences and philosophy, and his M.D degree from Harvard Medical School (1986).[2][3] Upon earning his medical degree, Saver completed a neurology residency at the Harvard-Longwood Program, ands fellowships in Behavioral and Cognitive Neurology at the University of Iowa and Vascular Neurology at Brown University.[4][5]

Career[edit]

Saver's academic career is marked by his association with the University of California, Los Angeles (UCLA), joining the faculty in 1994.He was founding Director of the UCLA Stroke Center and currently directs the UCLA NeuroTranslational Research Center.[6]

Internationally, he has served in leadership roles in the Virtual International Stroke Trials Archive (VISTA), the World Stroke Organization, and the International Classification of Diseases Neurosciences Division.[7]

Research[edit]

Saver has made research contributions to acute stroke treatment, stroke prevention, neuroimaging, clinical trial design, and neurocognitive consequences of stroke.[8][9] In the acute stroke domain, Saver led/co-led the development of clot retrieval therapy for stroke from its invention at UCLA the early 2000s through the pivotal breakthrough trials of 2015.[10] This highly effective treatment is now used worldwide.[11] His group also pioneered several aspects of prehospital treatment of stroke, including developing tools for paramedic identification of stroke, characterization of stroke severity, initiation of treatment within minutes of onset.[12] He also heightened recognition of stroke as an emergency condition by determining that the human brain loses 2 million nerve cells a minute during an ischemic stroke.[13]

In stroke prevention, Saver co-led the US trial of devices to prevent strokes by closing patent foramen ovale, an open channel in the upper chambers of the heart.[14] Closure device are the first effective therapy for this cause of 5% of all ischemic strokes. Also, his group developed the Stroke PROTECT program that served as a basis for the US national Get with the Guidelines – Stroke US quality of care registry.[15]

Honors and awards[edit]

Saver received the American Heart/Stroke Association's Stroke Council Award in 2006[16] and Distinguished Scientist Award in 2015 and the World Stroke Organization Research Award for lifetime contributions in 2018.[citation needed] He is an Honorary Fellow/Life Member of the European Stroke Organization, the Stroke Society of the Australasia, and the Royal College of Physicians of Thailand.[citation needed]

References[edit]

  1. ^ "Jeffrey Saver | UCLA Profiles". profiles.ucla.edu. Retrieved 2024-03-15.
  2. ^ "Jeffrey Saver, MD". WebMD. Retrieved 2024-03-15.
  3. ^ "Jeffrey L. Saver - Advisor at Astrocyte Pharmaceuticals". THE ORG. Retrieved 2024-03-15.
  4. ^ "Jeffrey L. Saver, MD - Vascular Neurology". www.uclahealth.org. Retrieved 2024-03-15.
  5. ^ "store.jcrinc.com" (PDF).
  6. ^ "UCLA Comprehensive Stroke Center honored for stroke care". UCLA. Retrieved 2024-03-15.
  7. ^ "ICD-11 is now officially in effect". World Stroke Organization. Retrieved 2024-03-15.
  8. ^ Miao, Zhongrong; Huo, Xiaochuan; Gao, Feng; Liao, Xiaoling; Wang, Chunjuan; Peng, Ya; Cao, Yibin; Chen, Shengli; Zhang, Meng; Jiang, Changchun; Peng, Xiaoxiang; Song, Cunfeng; Wei, Liping; Zhu, Qiyi; Guo, Zaiyu (2016-06-01). "Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China". Stroke and Vascular Neurology. 1 (2): 44–51. doi:10.1136/svn-2016-000022. ISSN 2059-8688. PMC 5435194. PMID 28959463.
  9. ^ Savitz, Sean I.; Benatar, Michael; Saver, Jeffrey L.; Fisher, Marc (2008-06-17). "Outcome Analysis in Clinical Trial Design for Acute Stroke: Physicians' Attitudes and Choices". Cerebrovascular Diseases. 26 (2): 156–162. doi:10.1159/000139663. ISSN 1015-9770.
  10. ^ Froehler, Michael T.; Saver, Jeffrey L.; Zaidat, Osama O.; Jahan, Reza; Aziz-Sultan, Mohammad Ali; Klucznik, Richard P.; Haussen, Diogo C.; Hellinger, Frank R.; Yavagal, Dileep R.; Yao, Tom L.; Liebeskind, David S.; Jadhav, Ashutosh P.; Gupta, Rishi; Hassan, Ameer E.; Martin, Coleman O. (2017-12-12). "Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment and Worse Outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke)". Circulation. 136 (24): 2311–2321. doi:10.1161/CIRCULATIONAHA.117.028920. ISSN 0009-7322. PMC 5732640. PMID 28943516.
  11. ^ Cajigal, Stephanie (2021-10-21). "Then and Now: 20 Years Later, Stroke Is a Treatable Condition". Neurology Today. 21 (20): 1, 27–28. doi:10.1097/01.NT.0000799964.27010.14. ISSN 1533-7006.
  12. ^ Saver, Jeffrey L.; Starkman, Sidney; Eckstein, Marc; Stratton, Samuel J.; Pratt, Franklin D.; Hamilton, Scott; Conwit, Robin; Liebeskind, David S.; Sung, Gene; Kramer, Ian; Moreau, Gary; Goldweber, Robert; Sanossian, Nerses (2015-02-05). "Prehospital Use of Magnesium Sulfate as Neuroprotection in Acute Stroke". New England Journal of Medicine. 372 (6): 528–536. doi:10.1056/NEJMoa1408827. ISSN 0028-4793. PMC 4920545. PMID 25651247.
  13. ^ "Stroke". www.uclahealth.org. Retrieved 2024-03-15.
  14. ^ Saver, Jeffrey L.; Carroll, John D.; Thaler, David E.; Smalling, Richard W.; MacDonald, Lee A.; Marks, David S.; Tirschwell, David L. (2017-09-14). "Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke". New England Journal of Medicine. 377 (11): 1022–1032. doi:10.1056/NEJMoa1610057. ISSN 0028-4793. PMID 28902590.
  15. ^ Ovbiagele, B.; Saver, J. L.; Fredieu, A.; Suzuki, S.; McNair, N.; Dandekar, A.; Razinia, T.; Kidwell, C. S. (2004-10-12). "PROTECT: A coordinated stroke treatment program to prevent recurrent thromboembolic events". Neurology. 63 (7): 1217–1222. doi:10.1212/01.WNL.0000140493.83607.F1. ISSN 0028-3878. PMID 15477541.
  16. ^ ohtadmin (2006-11-23). "T.O. resident gets American Heart Association award". Thousand Oaks Acorn -. Retrieved 2024-03-15.
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