MUPCDH

CDHR5
Identifiers
Aliases	CDHR5, MU-PCDH, MUCDHL, MUPCDH, MLPCDH, cadherin related family member 5
External IDs	OMIM: 606839 MGI: 1919290 HomoloGene: 69345 GeneCards: CDHR5
Gene location (Human)
Chr.	Chromosome 11 (human)
End	626,078 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,856,699 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; right lobe of liver; ; kidney; ; gallbladder; ; sural nerve; ; appendix; ; renal cortex; ; islet of Langerhans; ; stomach;
	Top expressed in
	duodenum; ; large intestine; ; colon; ; jejunum; ; crypt of lieberkuhn of small intestine; ; ileum; ; left colon; ; kidney; ; proximal tubule; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; beta-catenin binding; protein binding; cell adhesion molecule binding;
Cellular component	integral component of membrane; spanning component of plasma membrane; brush border membrane; clathrin-coated pit; plasma membrane; extracellular exosome; membrane; cell projection; microvillus membrane; apical plasma membrane;
Biological process	cell adhesion; regulation of microvillus length; homophilic cell adhesion via plasma membrane adhesion molecules; intermicrovillar adhesion; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	53841
	72040
	ENSG00000099834; ENSG00000273572
	ENSMUSG00000025497
	Q9HBB8
	Q8VHF2
	NM_001171968; NM_017717; NM_021924; NM_031264; NM_031265
	NM_001114322; NM_028069
	NP_001165439; NP_068743; NP_112554
	NP_001107794; NP_082345
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.^[5]^[6]^[7]

This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely.^[7]

References[edit]

^ ^a ^b ^c ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025497 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
^ Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.
^ ^a ^b "Entrez Gene: MUCDHL mucin and cadherin-like".

Further reading[edit]

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Goldberg M, Wei M, Tycko B, et al. (2002). "Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys". Am. J. Physiol. Renal Physiol. 283 (3): F454–63. doi:10.1152/ajprenal.00012.2002. PMID 12167596. S2CID 615952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Goldberg M, Wei M, Yuan L, et al. (2003). "Biallelic expression of HRAS and MUCDHL in human and mouse". Hum. Genet. 112 (4): 334–42. doi:10.1007/s00439-003-0907-7. PMID 12589428. S2CID 1143721.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025497 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11031102-5] Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.

[pmid10801787-6] Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.

[entrez-7] "Entrez Gene: MUCDHL mucin and cadherin-like".

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MUPCDH

References[edit]

Further reading[edit]

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