Marginal nucleus of spinal cord

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Posteromarginal nucleus
Medulla spinalis (Rexed lamina I labeled at upper left.)
Latinnucleus marginalis medullae spinalis, lamina spinalis I
Anatomical terms of neuroanatomy

The marginal nucleus of spinal cord, or posteromarginal nucleus, Rexed lamina I, is located at the most dorsal aspect of the dorsal horn of the spinal cord. The neurons located here receive input primarily from Lissauer's tract and relay information related to pain and temperature sensation.[1][2] Pain sensation relayed here cannot be modulated, e.g. pain from burning the skin. The axons of neurons contribute to the lateral spinothalamic tract.[3][4]


  1. ^ Dafny, Nachum (2020-10-07). "Anatomy of the Spinal Cord". Department of Neurobiology and Anatomy. 3 (2) – via University of Texas Health Science Center at Houston.
  2. ^ Almarestani, L.; Waters, S. M.; Krause, J. E.; Bennett, G. J.; Ribeiro-da-Silva, A. (2007-09-20). "Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat". The Journal of Comparative Neurology. 504 (3): 287–297. doi:10.1002/cne.21410. ISSN 0021-9967. PMID 17640051. S2CID 35818839.
  3. ^ Ganapathy, Muthu Kuzhali; Reddy, Vamsi; Tadi, Prasanna (2022), "Neuroanatomy, Spinal Cord Morphology", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31424790, retrieved 2023-01-20
  4. ^ Sheikh, Nafiz K.; Dua, Anterpreet (2022), "Neuroanatomy, Substantia Gelatinosa", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31855366, retrieved 2023-01-20