Protein-coding gene in the species Homo sapiens
Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene .[5] [6]
References [ edit ] Further reading [ edit ] Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions". Biochimie . 76 (3–4): 197–209. doi :10.1016/0300-9084(94)90147-3 . PMID 7819324 . Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression". Mol. Carcinog . 28 (2): 63–9. doi :10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C . PMID 10900462 . S2CID 22849623 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription" . Proc. Natl. Acad. Sci. U.S.A . 95 (5): 2192–7. Bibcode :1998PNAS...95.2192M . doi :10.1073/pnas.95.5.2192 PMC 19292 PMID 9482861 . Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III" . Mol. Cell . 1 (5): 749–57. doi :10.1016/S1097-2765(00)80074-X PMID 9660958 . Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis". Ann. N. Y. Acad. Sci . 921 : 333–9. doi :10.1111/j.1749-6632.2000.tb06988.x . PMID 11193847 . S2CID 46125753 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Qiu Q, Basak A, Mbikay M, et al. (2005). "Role of pro-IGF-II processing by proprotein convertase 4 in human placental development" . Proc. Natl. Acad. Sci. U.S.A . 102 (31): 11047–52. Bibcode :2005PNAS..10211047Q . doi :10.1073/pnas.0502357102 PMC 1182422 PMID 16040806 .
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