PHD finger protein 7

PHF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEQ
Identifiers
Aliases	PHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDs	MGI: 1919088 HomoloGene: 69217 GeneCards: PHF7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 52,410,660 bp[1] End 52,423,641 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 30,959,646 bp[2] End 30,973,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm sural nerve Achilles tendon rectum transverse colon gastric mucosa body of pancreas gastrocnemius muscle oocyte skin of abdomen Top expressed in seminiferous tubule spermatid spermatocyte Paneth cell internal carotid artery fossa external carotid artery corneal stroma condyle secondary oocyte More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51533 71838 Ensembl ENSG00000010318 ENSMUSG00000021902 UniProt Q9BWX1 Q9DAG9 RefSeq (mRNA) NM_001278221 NM_016483 NM_173341 NM_001321126 NM_001321127 NM_027949 NM_001360624 NM_001360625 RefSeq (protein) NP_001265150 NP_001308055 NP_001308056 NP_057567 NP_082225 NP_001347553 NP_001347554 Location (UCSC) Chr 3: 52.41 – 52.42 Mb Chr 14: 30.96 – 30.97 Mb PubMed search [3] [4]
Wikidata
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PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. ^[5]

Function[edit]

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

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