RAB6B

RAB6B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E9S, 2FE4, 2FFQ
Identifiers
Aliases	RAB6B, member RAS oncogene family
External IDs	OMIM: 615852 MGI: 107283 HomoloGene: 39749 GeneCards: RAB6B
Gene location (Human)
Chr.	Chromosome 3 (human)
End	133,895,882 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	103,062,475 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle temporal gyrus; ; pons; ; Brodmann area 46; ; orbitofrontal cortex; ; superior frontal gyrus; ; superior vestibular nucleus; ; parietal lobe; ; spinal ganglia;
	Top expressed in
	substantia nigra; ; trigeminal ganglion; ; medial dorsal nucleus; ; piriform cortex; ; prefrontal cortex; ; primary motor cortex; ; medial geniculate nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; temporal lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; myosin V binding; protein binding; GTPase activity;
Cellular component	Golgi membrane; membrane; cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; cytosol; Golgi apparatus; presynapse; intracellular anatomical structure;
Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein transport; intra-Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; vesicle-mediated transport; intracellular protein transport; Rab protein signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51560
	270192
	ENSG00000154917
	ENSMUSG00000032549
	Q9NRW1
	P61294
	NM_016577; NM_001363953
	NM_173781
	NP_057661; NP_001350882
	NP_776142
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032549 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAB6B RAB6B, member RAS oncogene family".

Further reading[edit]

Chen D, Guo J, Gahl WA (January 1997). "RAB GTPases expressed in human melanoma cells". Biochimica et Biophysica Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Garcia-Saez I, Tcherniuk S, Kozielski F (July 2006). "The structure of human neuronal Rab6B in the active and inactive form". Acta Crystallographica Section D. 62 (Pt 7): 725–33. doi:10.1107/S0907444906015319. PMID 16790928.
Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (October 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.