Protein-coding gene in the species Homo sapiens
Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene .[ 5] [ 6] [ 7]
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase -activating proteins for Gi (see GNAI1 ; MIM 139310) and Gq (see GNAQ ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][ 7]
In melanocytic cells RGS20 gene expression may be regulated by MITF .[ 8]
RGS20 has been shown to interact with GNAO1 [ 9] GNAZ .[ 5] [ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000147509 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002459 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha" . The Journal of Biological Chemistry . 273 (40): 26008–13. doi :10.1074/jbc.273.40.26008 PMID 9748279 . ^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (October 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily" . The Journal of Biological Chemistry . 273 (40): 26014–25. doi :10.1074/jbc.273.40.26014 PMID 9748280 . ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20" .^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell & Melanoma Research . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 . S2CID 24698373 . ^ Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (June 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways" . Cellular Signalling . 20 (6): 1190–7. doi :10.1016/j.cellsig.2008.02.008 . PMC 3107604 PMID 18407463 . ^ Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus" . Journal of Cell Science . 115 (Pt 23): 4483–93. doi :10.1242/jcs.00093 PMID 12414994 . Barker SA, Wang J, Sierra DA, Ross EM (December 2001). "RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20". Genomics . 78 (3): 223–9. doi :10.1006/geno.2001.6659 . PMID 11735229 . Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics . 79 (2): 177–85. doi :10.1006/geno.2002.6693 . PMID 11829488 . S2CID 16065132 . Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly" . The Journal of Biological Chemistry . 277 (20): 18127–33. doi :10.1074/jbc.M201065200 PMID 11882662 . Wang Y, Ho G, Zhang JJ, Nieuwenhuijsen B, Edris W, Chanda PK, Young KH (December 2002). "Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling" . The Journal of Biological Chemistry . 277 (50): 48325–32. doi :10.1074/jbc.M206116200 PMID 12379657 . Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus" . Journal of Cell Science . 115 (Pt 23): 4483–93. doi :10.1242/jcs.00093 PMID 12414994 . Fischer T, De Vries L, Meerloo T, Farquhar MG (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP" . Proceedings of the National Academy of Sciences of the United States of America . 100 (14): 8270–5. Bibcode :2003PNAS..100.8270F . doi :10.1073/pnas.1432965100 PMC 166218 PMID 12826607 . Xu GY, Hum WT, Sukits SF, Hsiao CL, Liu Y, Malakian K, et al. (April 2004). "1H, 13C and 15N resonance assignments of human RGSZ1". Journal of Biomolecular NMR . 28 (4): 409–10. doi :10.1023/B:JNMR.0000015374.29659.f9 . PMID 14872136 . S2CID 45949960 . Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH (April 2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cellular Signalling . 19 (4): 723–30. doi :10.1016/j.cellsig.2006.09.008 . PMID 17126529 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
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