Protein-coding gene in the species Homo sapiens
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene .[ 5]
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins . This family contains proteins that are related to Drosophila rhomboid-1 . Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases .
RHBDL2 functions as a sheddase and is localized to the plasma membrane .[ 6] thrombomodulin and epidermal growth factor ;[ 6] type I membrane proteins substrates, including BCAM , SPINT1 , and CLCP1 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000158315 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043333 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)" .^ a b Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments" . The EMBO Journal . 37 (15). doi :10.15252/embj.201899456 . PMC 6068445 PMID 29976761 . ^ Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (August 2017). "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis" . Scientific Reports . 7 (1): 7283. Bibcode :2017NatSR...7.7283J . doi :10.1038/s41598-017-07556-3 . PMC 5544772 PMID 28779096 . Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (May 2011). "Mammalian EGF receptor activation by the rhomboid protease RHBDL2" . EMBO Reports . 12 (5): 421–7. doi :10.1038/embor.2011.50 . PMC 3090019 PMID 21494248 . Pascall JC, Brown KD (April 2004). "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2". Biochemical and Biophysical Research Communications . 317 (1): 244–52. doi :10.1016/j.bbrc.2004.03.039 . PMID 15047175 . Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, et al. (December 2011). "Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing" . The Journal of Investigative Dermatology . 131 (12): 2486–94. doi :10.1038/jid.2011.230 PMID 21833011 . Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. (February 2010). "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer" . Proceedings of the National Academy of Sciences of the United States of America . 107 (5): 2136–40. Bibcode :2010PNAS..107.2136X . doi :10.1073/pnas.0914061107 PMC 2836698 PMID 20080650 . Urban S, Freeman M (June 2003). "Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain" . Molecular Cell . 11 (6): 1425–34. doi :10.1016/s1097-2765(03)00181-3 PMID 12820957 . Urban S, Lee JR, Freeman M (October 2001). "Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases" . Cell . 107 (2): 173–82. doi :10.1016/s0092-8674(01)00525-6 PMID 11672525 . S2CID 9026083 . Lei X, Li YM (December 2009). "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity". Journal of Molecular Biology . 394 (5): 815–25. doi :10.1016/j.jmb.2009.10.025 . PMID 19850051 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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