Transforming growth factor, beta 3

TGFB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KTZ, 1TGJ, 1TGK, 2PJY, 3EO1, 4UM9
Identifiers
Aliases	TGFB3, ARVD, ARVD1, RNHF, TGF-beta3, Transforming growth factor, beta 3, LDS5, transforming growth factor beta 3, TGF beta 3
External IDs	OMIM: 190230; MGI: 98727; HomoloGene: 2433; GeneCards: TGFB3; OMA:TGFB3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,958,097 bp[1] End 75,983,011 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D2|12 40.09 cM Start 86,103,519 bp[2] End 86,125,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein canal of the cervix gallbladder prostate cartilage tissue smooth muscle tissue body of pancreas periodontal fiber body of uterus C1 segment Top expressed in external carotid artery molar aortic valve internal carotid artery lactiferous gland ascending aorta ankle umbilical cord ankle joint calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function type III transforming growth factor beta receptor binding cytokine activity type I transforming growth factor beta receptor binding protein binding protein heterodimerization activity transforming growth factor beta receptor binding growth factor activity transforming growth factor beta binding type II transforming growth factor beta receptor binding identical protein binding Cellular component cytoplasm extracellular matrix T-tubule plasma membrane secretory granule cell surface soma platelet alpha granule lumen nucleus extracellular region extracellular space intracellular membrane-bounded organelle collagen-containing extracellular matrix Biological process regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of collagen biosynthetic process cell-cell junction organization regulation of MAPK cascade SMAD protein signal transduction positive regulation of bone mineralization embryonic neurocranium morphogenesis response to progesterone female pregnancy response to laminar fluid shear stress ageing platelet degranulation in utero embryonic development negative regulation of transforming growth factor beta receptor signaling pathway wound healing salivary gland morphogenesis mammary gland development odontogenesis response to estrogen positive regulation of protein secretion ossification involved in bone remodeling uterine wall breakdown frontal suture morphogenesis inner ear development negative regulation of macrophage cytokine production lung alveolus development digestive tract development transforming growth factor beta receptor signaling pathway positive regulation of filopodium assembly positive regulation of cell division face morphogenesis detection of hypoxia positive regulation of transcription by RNA polymerase II positive regulation of SMAD protein signal transduction positive regulation of tight junction disassembly positive regulation of epithelial to mesenchymal transition positive regulation of stress fiber assembly regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of apoptotic process response to hypoxia positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of transcription, DNA-templated negative regulation of vascular associated smooth muscle cell proliferation BMP signaling pathway cell development regulation of signaling receptor activity positive regulation of cell population proliferation negative regulation of cell population proliferation secondary palate development regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7043 21809 Ensembl ENSG00000119699 ENSMUSG00000021253 UniProt P10600 P17125 RefSeq (mRNA) NM_003239 NM_001329938 NM_001329939 NM_009368 RefSeq (protein) NP_001316867 NP_001316868 NP_003230 n/a Location (UCSC) Chr 14: 75.96 – 75.98 Mb Chr 12: 86.1 – 86.13 Mb PubMed search [3] [4]
Wikidata
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Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.^[5][6]

It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.^[7]

TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.^[8][9] This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue,^[10] and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.^[5]

Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.^{[11][12][13][14]}

After successful phase I/II trials,^[15] human recombinant TGF-β3 (avotermin, planned trade name Juvista) failed in Phase III trials.^[16]

• GeneReviews/NCBI/NIH/UW entry on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
• OMIM entries on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
• Overview of all the structural information available in the PDB for UniProt: P10600 (Transforming growth factor beta-3) at the PDBe-KB.