TM4SF5

TM4SF5
Identifiers
Aliases	TM4SF5, transmembrane 4 L six family member 5
External IDs	OMIM: 604657 MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,783,213 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,402,004 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; duodenum; ; kidney tubule; ; rectum; ; kidney; ; glomerulus; ; metanephric glomerulus; ; body of stomach; ; gallbladder;
	Top expressed in
	duodenum; ; jejunum; ; crypt of lieberkuhn of small intestine; ; ileum; ; intestinal epithelium; ; mucous cell of stomach; ; intestinal villus; ; epithelium of stomach; ; Paneth cell; ; yolk sac;
	More reference expression data
	More reference expression data
Orthologs
	9032
	75604
	ENSG00000142484
	ENSMUSG00000018919
	O14894
	n/a
	NM_003963
	NM_029360
	NP_003954
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142484 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.
^ ^a ^b "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".

Further reading[edit]

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Lee SY, Kim YT, Lee MS, et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment". Exp. Cell Res. 312 (16): 2983–99. doi:10.1016/j.yexcr.2006.06.001. hdl:10371/3238. PMID 16828471.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". Am. J. Gastroenterol. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983. S2CID 31864317.
Wright MD, Ni J, Rudy GB (2000). "The L6 membrane proteins--a new four-transmembrane superfamily". Protein Sci. 9 (8): 1594–600. doi:10.1110/ps.9.8.1594. PMC 2144728. PMID 10975581.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142484 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018919 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479038-5] Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.

[entrez-6] "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".

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[6]

TM4SF5

References[edit]

Further reading[edit]

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