TMPRSS11D

TMPRSS11D
Identifiers
Aliases	TMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP
External IDs	OMIM: 605369; MGI: 2385221; HomoloGene: 74519; GeneCards: TMPRSS11D; OMA:TMPRSS11D - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,884,002 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,521,279 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; cervix epithelium; ; oral cavity; ; body of tongue; ; amniotic fluid; ; mucosa of pharynx; ; buccal mucosa cell; ; periodontal fiber; ; human penis;
	Top expressed in
	esophagus; ; external naris; ; mucosa of esophagus; ; epithelium of esophagus; ; lip; ; cervix; ; cornea; ; stomach; ; neural layer of retina; ; lacrimal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	respiratory gaseous exchange by respiratory system; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9407
	231382
	ENSG00000153802
	ENSMUSG00000061259
	O60235
	Q8VHK8
	NM_004262
	NM_145561
	NP_004253
	NP_663536
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.^[5]^[6]^[7]

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153802 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061259 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
^ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
^ ^a ^b "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D". Archived from the original on 2024-04-30. Retrieved 2017-09-15.

Overview of all the structural information available in the PDB for UniProt: Q8VHK8 (Mouse Transmembrane protease serine 11D) at the PDBe-KB.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.