UBE4A

UBE4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGM
Identifiers
Aliases	UBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
External IDs	OMIM: 603753; MGI: 2154580; HomoloGene: 3517; GeneCards: UBE4A; OMA:UBE4A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,399,211 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,876,898 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; visceral pleura; ; parietal pleura; ; pons; ; skin of thigh; ; trigeminal ganglion; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	muscle of thigh; ; neural layer of retina; ; genital tubercle; ; spermatocyte; ; ganglion of vagus nerve; ; granulocyte; ; zygote; ; tail of embryo; ; yolk sac; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; transferase activity; ubiquitin-ubiquitin ligase activity;
Cellular component	ubiquitin ligase complex; nucleus; cytoplasm;
Biological process	protein ubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9354
	140630
	ENSG00000110344
	ENSMUSG00000059890
	Q14139
	E9Q735
	NM_004788; NM_001204077
	NM_145400; NM_001346698; NM_001361075; NM_001361076
	NP_001191006; NP_004779
	NP_001333627; NP_663375; NP_001348004; NP_001348005
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.^[5]^[6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059890 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
^ ^a ^b "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)".

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues". Gene. 328: 69–74. doi:10.1016/j.gene.2003.11.017. PMID 15019985.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation". Cell Cycle. 3 (12): 1638–44. doi:10.4161/cc.3.12.1345. PMID 15611659.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110344 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059890 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10089879-5] Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.

[entrez-6] "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)".

[1]

[2]

[3]

[4]

[5]

[6]

UBE4A

References

Further reading

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