ZNF444

ZNF444
Identifiers
Aliases	ZNF444, EZF-2, EZF2, ZSCAN17, zinc finger protein 444
External IDs	OMIM: 607874 MGI: 1923365 HomoloGene: 10139 GeneCards: ZNF444
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,160,893 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,196,810 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; vena cava; ; right uterine tube; ; right lobe of liver; ; cerebellar vermis; ; body of pancreas; ; thoracic diaphragm; ; cingulate gyrus; ; pancreatic ductal cell; ; fundus;
	Top expressed in
	yolk sac; ; spermatocyte; ; superior frontal gyrus; ; proximal tubule; ; neural tube; ; thymus; ; spermatid; ; ganglionic eminence; ; lip; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding; metal ion binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	55311
	72667
	ENSG00000167685
	ENSMUSG00000044876
	Q8N0Y2
	n/a
	NM_001253792; NM_018337
	NM_001146024; NM_028316
	NP_001240721; NP_060807; NP_001240721.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene. ^[5]

Function[edit]

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) (Adachi H, Tsujimoto M (2002). "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem. 277 (27): 24014–21. doi:10.1074/jbc.M201854200. PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044876 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 444". Retrieved 2017-04-14.