40S ribosomal protein S3a is a protein that in humans is encoded by the RPS3Agene.[5][6][7]
Ribosomes, the organelles that catalyzeprotein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. Transcript variants utilizing alternative transcription start sites have been described. This gene is co-transcribed with the U73A and U73Bsmall nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nolte D, Taimor G, Kalff-Suske M, Seifart KH (July 1996). "The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene". Gene. 169 (2): 179–85. doi:10.1016/0378-1119(95)00708-3. PMID8647443.
^Metspalu A, Rebane A, Hoth S, Pooga M, Stahl J, Kruppa J (November 1992). "Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein". Gene. 119 (2): 313–6. doi:10.1016/0378-1119(92)90289-2. PMID1398113.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID8076819.
Kho CJ, Wang Y, Zarbl H (1997). "Effect of decreased fte-1 gene expression on protein synthesis, cell growth, and transformation". Cell Growth Differ. 7 (9): 1157–66. PMID8877097.
Rebane A, Tamme R, Laan M, et al. (1998). "A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes". Gene. 210 (2): 255–63. doi:10.1016/S0378-1119(98)00070-5. PMID9573378.
Song D, Sakamoto S, Taniguchi T (2002). "Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a". Biochemistry. 41 (3): 929–34. doi:10.1021/bi015669c. PMID11790116.