OR2AG1
| OR2AG1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR2AG1, OR11-79, OR2AG3, olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene), olfactory receptor family 2 subfamily AG member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3030539; HomoloGene: 128075; GeneCards: OR2AG1; OMA:OR2AG1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
[edit]Amyl butyrate is a reported ligand for this receptor. [6]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000279486 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000109058 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1".
- ^ Shepard BD, Pluznick JL (May 2016). "How does your kidney smell? Emerging roles for olfactory receptors in renal function". Pediatric Nephrology (Berlin, Germany). 31 (5): 715–23. doi:10.1007/s00467-015-3181-8. PMC 4752438. PMID 26264790.
Further reading
[edit]- Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi:10.1073/pnas.131215398. PMC 34679. PMID 11416212.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Neuhaus EM, Mashukova A, Zhang W, et al. (2006). "A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins". Chem. Senses. 31 (5): 445–52. doi:10.1093/chemse/bjj049. PMID 16565291.
- Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006). "Beta-arrestin2-mediated internalization of mammalian odorant receptors". J. Neurosci. 26 (39): 9902–12. doi:10.1523/JNEUROSCI.2897-06.2006. PMC 6674477. PMID 17005854.
External links
[edit]- OR2AG1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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