OR2T4
| OR2T4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR2T4, OR1-60, OR2T4Q, olfactory receptor family 2 subfamily T member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3030058; HomoloGene: 133015; GeneCards: OR2T4; OMA:OR2T4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
[edit]OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:
See also
[edit]References
[edit]- ^ a b c ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059279 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".
- ^ Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC 6482435. PMID 30977365.
Further reading
[edit]- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
[edit]- OR2T4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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