ADCYAP1R1

ADCYAP1R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JOD
Identifiers
Aliases	ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI, ADCYAP receptor type I
External IDs	OMIM: 102981; MGI: 108449; HomoloGene: 870; GeneCards: ADCYAP1R1; OMA:ADCYAP1R1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	31,111,479 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,478,436 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; nucleus accumbens; ; caudate nucleus; ; amygdala; ; entorhinal cortex; ; right frontal lobe; ; internal globus pallidus; ; cingulate gyrus; ; anterior cingulate cortex; ; right hemisphere of cerebellum;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; dentate gyrus of hippocampal formation granule cell; ; arcuate nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; substantia nigra; ; lateral hypothalamus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; adenylate cyclase binding; neuropeptide binding; vasoactive intestinal polypeptide receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; signaling receptor activity; G protein-coupled peptide receptor activity; peptide hormone binding;
Cellular component	cytoplasm; integral component of membrane; endosome; rough endoplasmic reticulum; membrane; bicellular tight junction; receptor complex; plasma membrane; integral component of plasma membrane; cell surface; caveola; neuron projection; intracellular membrane-bounded organelle;
Biological process	cell differentiation; multicellular organismal response to stress; response to estradiol; positive regulation of calcium ion transport into cytosol; positive regulation of inositol phosphate biosynthetic process; negative regulation of cell death; activation of phospholipase C activity; multicellular organism development; cell surface receptor signaling pathway; development of primary female sexual characteristics; spermatogenesis; response to ethanol; cAMP-mediated signaling; signal transduction; positive regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	117
	11517
	ENSG00000078549
	ENSMUSG00000029778
	P41586
	P70205
	NM_001118; NM_001199635; NM_001199636; NM_001199637
	NM_001025372; NM_007407
	NP_001109; NP_001186564; NP_001186565; NP_001186566
	NP_001020543; NP_031433
	Wikidata
View/Edit Human	View/Edit Mouse

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC₁, is a protein that in humans is encoded by the ADCYAP1R1 gene.^[5] This receptor binds pituitary adenylate cyclase activating peptide.^[6]^[7]

Function

PAC₁ is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family.^[8] This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.^[5] PAC₁ is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.^[9]^[10]^[11] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078549 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".
^ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
^ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.
^ Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y (2020). "Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism". Cell Res. 30 (5): 436–445. doi:10.1038/s41422-020-0280-2. PMC 7196072. PMID 32047270.
^ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921 (1): 1–25. Bibcode:2000NYASA.921....1R. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811. S2CID 21204750.
^ Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.
^ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation" (PDF). The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jcem.83.4.4690. PMID 9543159.
^ Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171. S2CID 30329669.

External links

"VIP and PACAP Receptors: PAC₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Human ADCYAP1R1 genome location and ADCYAP1R1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078549 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029778 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".

[pmid7902709-6] Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.

[pmid10835102-7] Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.

[pmid32047270-8] Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y (2020). "Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism". Cell Res. 30 (5): 436–445. doi:10.1038/s41422-020-0280-2. PMC 7196072. PMID 32047270.

[pmid11193811-9] Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921 (1): 1–25. Bibcode:2000NYASA.921....1R. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811. S2CID 21204750.

[pmid10850463-10] Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.

[pmid9543159-11] Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation" (PDF). The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jcem.83.4.4690. PMID 9543159.

[Knutsson-2002-12] Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171. S2CID 30329669.

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ADCYAP1R1

Function

References

Further reading

External links

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