25-羥基維生素D3 1-α-羥化酶 |
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識別號 |
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别名 | CYP27B1;, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1 |
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外部ID | OMIM:609506 MGI:1098274 HomoloGene:37139 GeneCards:CYP27B1 |
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EC number | 1.14.15.18 |
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相關疾病 |
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1-alpha-hydroxylase deficiency[1] |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 12: 57.76 – 57.77 Mb | Chr 10: 126.88 – 126.89 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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细胞色素 P450 27B1(英語:Cytochrome P450 27B1,缩写CYP27B1)也被称为25-羟基维生素 D3 1-α-羟化酶(25-Hydroxyvitamin D3 1-alpha-hydroxylase,EC 1.14.15.18),是细胞色素P450超家族的一员,由CYP27B1基因编码,定位于线粒体内膜[6][7][8],在许多组织细胞中表达,如腎的近曲小管、皮肤角质形成细胞、免疫细胞[9]、成骨细胞等[10],催化骨化二醇羟基化生成骨化三醇(维生素D的活性形式)[11]:
- 骨化二醇 + 2 还原型 Adx + 2 H+ + O2 ⇌ 骨化三醇 + 2 氧化型 Adx + H2O
参考文献[编辑]
- ^ 與25-羥基維生素D3 1-α-羥化酶相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000111012 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000006724 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Entrez Gene: cytochrome P450. (原始内容存档于2009-05-11).
- ^ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. Sep 1997, 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.
- ^ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications. Oct 1997, 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.
- ^ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (PDF). Nature Immunology. Mar 2007, 8 (3): 285–93 [2020-04-30]. PMID 17259988. doi:10.1038/ni1433. (原始内容 (PDF)存档于2020-03-19).
- ^ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology. Oct 2010, 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334 .
- ^ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. The Journal of Biological Chemistry. Dec 1972, 247 (23): 7528–32. PMID 4404596. doi:10.1016/S0021-9258(19)44557-2.
外部链接[编辑]
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| CYP1 | |
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| CYP2 | |
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| CYP3 | |
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| CYP4 | |
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| CYP5-20 | |
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| CYP21-49 | |
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| CYP51-69 | |
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| CYP101-281 | |
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| CYP301-499 | |
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