CYP27B1
细胞色素 P450 27B1（英語：Cytochrome P450 27B1，缩写CYP27B1）也被称为25-羟基维生素 D3 1-α-羟化酶（25-Hydroxyvitamin D3 1-alpha-hydroxylase，EC 1.14.15.18），是细胞色素P450超家族的一员，由CYP27B1基因编码，定位于线粒体内膜[6][7][8]，在许多组织细胞中表达，如腎的近曲小管、皮肤角质形成细胞、免疫细胞[9]、成骨细胞等[10]，催化骨化二醇羟基化生成骨化三醇（维生素D的活性形式）[11]：
- 骨化二醇 + 2 还原型 Adx + 2 H+ + O2 ⇌ 骨化三醇 + 2 氧化型 Adx + H2O
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参考文献
[编辑]- ^ 與25-羥基維生素D3 1-α-羥化酶相關的疾病；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000111012 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000006724 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Entrez Gene: cytochrome P450. （原始内容存档于2009-05-11）.
- ^ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. Sep 1997, 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.
- ^ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications. Oct 1997, 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.
- ^ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (PDF). Nature Immunology. Mar 2007, 8 (3): 285–93 [2020-04-30]. PMID 17259988. doi:10.1038/ni1433. （原始内容 (PDF)存档于2020-03-19）.
- ^ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology. Oct 2010, 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334
. - ^ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. The Journal of Biological Chemistry. Dec 1972, 247 (23): 7528–32. PMID 4404596. doi:10.1016/S0021-9258(19)44557-2.
外部链接
[编辑]- GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis（页面存档备份，存于互联网档案馆）
- 醫學主題詞表（MeSH）：Cytochrome+P-450+CYP27A1
- Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser.