Vezikulski inhibitorni aminokiselinski transporter

Vezikulski inhibitorni aminokiselinski transporter
Identifikatori
Aliasi	SLC32A1
Vanjski ID-jevi	OMIM: 616440 MGI: 1194488 HomoloGene: 56451 GeneCards: SLC32A1
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	38,729,372 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	158,457,668 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• glycine transmembrane transporter activity; • amino acid transmembrane transporter activity; • gamma-aminobutyric acid:proton symporter activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • Sinapsna vezikula; • ćelijska membrana; • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; • sinapsa; • inhibitory synapse; • synaptic vesicle membrane; • presynaptic active zone; • dendrite terminus; • dendrit; • cone cell pedicle; • intracellular organelle; • cell tip; • neuron projection; • neuron projection terminus; • cytoplasmic vesicle membrane; • GO:0016023 citoplazmatska vezikula; • integral component of synaptic vesicle membrane; • GABA-ergic synapse;
Biološki proces	• amino acid transmembrane transport; • GO:0010260 starenje; • ion transport; • gamma-aminobutyric acid transport; • neurotransmitter transport; • hippocampus development; • GO:0010554 neurotransmitter secretion; • glycine transport; • neurotransmitter loading into synaptic vesicle;
	Izvori:Amigo / QuickGO
Ortolozi
	140679
	22348
	ENSG00000101438
	ENSMUSG00000037771
	Q9H598
	O35633
	NM_080552
	NM_009508
	NP_542119
	NP_033534
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vezikulski inhibitorni aminokiselinski transporter jest protein koji je kod ljudi kodiran genom SLC32A1 sa hromosoma 20.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 525 aminokiselina, a molekulska težina 57.415 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATLLRSKLS	NVATSVSNKS	QAKMSGMFAR	MGFQAATDEE	AVGFAHCDDL
DFEHRQGLQM	DILKAEGEPC	GDEGAEAPVE	GDIHYQRGSG	APLPPSGSKD
QVGGGGEFGG	HDKPKITAWE	AGWNVTNAIQ	GMFVLGLPYA	ILHGGYLGLF
LIIFAAVVCC	YTGKILIACL	YEENEDGEVV	RVRDSYVAIA	NACCAPRFPT
LGGRVVNVAQ	IIELVMTCIL	YVVVSGNLMY	NSFPGLPVSQ	KSWSIIATAV
LLPCAFLKNL	KAVSKFSLLC	TLAHFVINIL	VIAYCLSRAR	DWAWEKVKFY
IDVKKFPISI	GIIVFSYTSQ	IFLPSLEGNM	QQPSEFHCMM	NWTHIAACVL
KGLFALVAYL	TWADETKEVI	TDNLPGSIRA	VVNIFLVAKA	LLSYPLPFFA
AVEVLEKSLF	QEGSRAFFPA	CYSGDGRLKS	WGLTLRCALV	VFTLLMAIYV
PHFALLMGLT	GSLTGAGLCF	LLPSLFHLRL	LWRKLLWHQV	FFDVAIFVIG
GICSVSGFVH	SLEGLIEAYR	TNAED

Funkcija

Protein kodiran ovim genom je integralni membranski protein uključen u gama-aminobuternu kiselinu (GABA) i unos glicina u sinapsne vezikule. Kodirani protein je član porodice transportera amino kiselina/poliamina II.^[5]

Također pogledajte

Porodica rastvornih nosača

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101438 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037771 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

Dopunska literatura

McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821. S2CID 4404823.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901. S2CID 23696667.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963.
Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694. S2CID 27646744.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. PMID 12806177. S2CID 7652352.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Šablon:Modulatori GABA metabolizma i transporta

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101438 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037771 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

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