From Wikipedia the free encyclopedia


Keratoglobus (from Greek: kerato- horn, cornea; and Latin: globus round) is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to become extremely thin and change to a more globular shape than its normal gradual curve. It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye.

It is sometimes equated with "megalocornea".[1]


Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print. It does not however lead to blindness.


Treatment includes the use of protective eye glasses.[2] A number of surgical options are also available.[2]

Further progression of the disease usually leads to a need for corneal transplantation because of extreme thinning of the cornea. Primarily, large size penetrating keratoplasty has been advocated. Recent additions of techniques specifically for keratoglobus include the "tuck procedure",[3] whereby a 12 mm corneo-scleral donor graft is taken and trimmed at its outer edges. A host pocket is formed at the limbal margin and the donor tissue is "tucked" into the host pocket.


Keratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. The patient is at risk for globe perforation because the thinned out cornea is extremely weak.


It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea.[4] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and thirties.


  1. ^ "keratoglobus" at Dorland's Medical Dictionary
  2. ^ a b Wallang, BS; Das, S (September 2013). "Keratoglobus". Eye. 27 (9). London: 1004–1212. doi:10.1038/eye.2013.130. PMC 3772364. PMID 23807384.
  3. ^ Kaushal S, Jhanji V, Sharma N, Tandon R, Titiyal JS, Vajpayee RB (February 2008). ""Tuck In" Lamellar Keratoplasty (TILK) for corneal ectasias involving corneal periphery". Br J Ophthalmol. 92 (2): 286–290. doi:10.1136/bjo.2007.124628. PMID 18227208. S2CID 36981311.[permanent dead link]
  4. ^ "Review of Optometry". Archived from the original on 2007-03-10. Retrieved 2006-10-17.

External links[edit]