Monokine
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A monokine is a type of cytokine[1] produced primarily by monocytes and macrophages.
Some monokines are:
- interleukin 1[2]
- tumor necrosis factor-alpha[2]
- alpha and beta interferon[3]
- colony stimulating factors [3]
Functions[edit]
Monokines released from macrophages can attract neutrophils, via the process chemotaxis.
The secretion of monokine, prompted by interferon gamma, has activity for the receptors found within immune cells, such as T-cells, hindering their ability to function as regulators of the body. Thus, promoting tumor progression in the cancer-state.[4] In fact, its activity is important in other diseases, such as pulmonary tuberculosis, where researchers have identified monokine as a biomarker.[5]
See also[edit]
References[edit]
- ^ Monokines at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ a b Leung DY, Geha RS, Newburger JW (1986). "Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome". The Journal of Experimental Medicine. 164 (6): 1958–72. doi:10.1084/jem.164.6.1958. PMC 2188474. PMID 3491174.
- ^ a b Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.
- ^ Bolomsky, Arnold; Schreder, Martin; Hübl, Wolfgang; Zojer, Niklas; Hilbe, Wolfgang; Ludwig, Heinz (November 2016). "Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma". Leukemia & Lymphoma. 57 (11): 2516–2525. doi:10.3109/10428194.2016.1151511. ISSN 1042-8194. PMID 26999330.
- ^ Li, Yang; He, Dengqi; Che, Yinfu; Zhao, Xinchen (2020-11-20). "Monokine induced by gamma interferon for detecting pulmonary tuberculosis: A diagnostic meta-analysis". Medicine. 99 (47): e23302. doi:10.1097/MD.0000000000023302. ISSN 0025-7974. PMC 7676613. PMID 33217864.
External links[edit]
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