OR1A2

OR1A2
Identifiers
Aliases	OR1A2, OR17-6, olfactory receptor family 1 subfamily A member 2
External IDs	OMIM: 618047 GeneCards: OR1A2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 3,197,519 bp[1] End 3,198,448 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood multicellular organism n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process positive regulation of cytokinesis sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26189 n/a Ensembl ENSG00000172150 n/a UniProt Q9Y585 n/a RefSeq (mRNA) NM_012352 n/a RefSeq (protein) NP_036484 n/a Location (UCSC) Chr 17: 3.2 – 3.2 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.^[3][4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[4]

Ligands[edit]

The known ligands of OR1A2 are near-identical to those of OR1A1.^[5] Examples of known ligands, most of which have citrus or fruity smells:^[5][6]

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal^[5])
• Hydroxycitronellal
• Citral
• (S)-(−)-Citronellol (in contrast to OR1A1 only this enantiomer is effective; weaker than citronellal^[5])

See also[edit]

• Olfactory receptor

Notes[edit]

References[edit]

• This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading[edit]

External links[edit]

• OR1A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)