Protein-coding gene in the species Homo sapiens
U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene .[5] [6]
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[6]
References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000125870 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008333 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen" . Proc Natl Acad Sci U S A . 84 (8): 2421–5. Bibcode :1987PNAS...84.2421H . doi :10.1073/pnas.84.8.2421 PMC 304663 PMID 2951739 . ^ a b "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B" . Further reading [ edit ] Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins" . J. Cell Biol . 110 (4): 871–81. doi :10.1083/jcb.110.4.871 . PMC 2116108 PMID 2139037 . Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E." Nucleic Acids Res . 25 (2): 354–61. doi :10.1093/nar/25.2.354 . PMC 146436 PMID 9016565 . Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013–21. doi :10.1016/S0092-8674(00)80367-0 PMID 9323129 . S2CID 10855404 . Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles" . Biochem. J . 332 (1): 135–44. doi :10.1042/bj3320135 . PMC 1219461 PMID 9576861 . Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature . 394 (6694): 645–50. Bibcode :1998Natur.394..645P . doi :10.1038/29234 . PMID 9716128 . S2CID 204999419 . Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet . 20 (1): 46–50. doi :10.1038/1700 . PMID 9731529 . S2CID 585778 . Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy" . Hum. Mol. Genet . 8 (13): 2351–7. doi :10.1093/hmg/8.13.2351 PMID 10556282 . Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II" . J. Cell Biol . 152 (1): 75–85. doi :10.1083/jcb.152.1.75 . PMC 2193649 PMID 11149922 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature . 414 (6866): 929–33. doi :10.1038/414929a . PMID 11780068 . S2CID 1518837 . Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39. doi :10.1017/S1355838202021088 . PMC 1370266 PMID 11991638 . Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process". Biochim. Biophys. Acta . 1576 (3): 287–97. doi :10.1016/S0167-4781(02)00368-8 . PMID 12084575 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol . 23 (1): 94–101. doi :10.1038/nbt1046 . PMID 15592455 . S2CID 7200157 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
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