23S rRNA (uridine2552-2'-O)-methyltransferase
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| 23S rRNA (uridine2552-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.166 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (uridine2552-2'-O)-methyltransferase (EC 2.1.1.166, Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + uridine2552 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.
References[edit]
- ^ Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G (June 2000). "The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase". The Journal of Biological Chemistry. 275 (22): 16414–9. doi:10.1074/jbc.M001854200. PMID 10748051.
- ^ Hager J, Staker BL, Bugl H, Jakob U (November 2002). "Active site in RrmJ, a heat shock-induced methyltransferase". The Journal of Biological Chemistry. 277 (44): 41978–86. doi:10.1074/jbc.M205423200. PMID 12181314.
- ^ Hager J, Staker BL, Jakob U (October 2004). "Substrate binding analysis of the 23S rRNA methyltransferase RrmJ". Journal of Bacteriology. 186 (19): 6634–42. doi:10.1128/JB.186.19.6634-6642.2004. PMC 516604. PMID 15375145.
- ^ Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U (August 2000). "RNA methylation under heat shock control". Molecular Cell. 6 (2): 349–60. doi:10.1016/S1097-2765(00)00035-6. PMID 10983982.
External links[edit]
- 23S+rRNA+(uridine2552-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
