Diamine N-acetyltransferase
From Wikipedia the free encyclopedia
| diamine N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Spermidine N-acetyltransferase dodekamer, Vibrio cholerae | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.57 | ||||||||
| CAS no. | 54596-36-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a diamine N-acetyltransferase (EC 2.3.1.57) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + an alkane-alpha,omega-diamine CoA + an N-acetyldiamine
Thus, the two substrates of this enzyme are acetyl-CoA and alkane-alpha,omega-diamine, whereas its two products are CoA and N-acetyldiamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, and putrescine N-acetyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.
Structural studies[edit]
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2BEI, 2F5I, 2FXF, 2G3T, 2JEV, and 2Q4V.
References[edit]
- Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver". Biochemistry. 21 (24): 6152–8. doi:10.1021/bi00267a020. PMID 7150547.
