N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
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| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.33 | ||||||||
| CAS no. | 242469-38-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.[1][2] This enzyme catalyses the following chemical reaction
- (1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
- (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
The enzyme is activated by divalent cations and reduced glutathione.
Human proteins containing this domain[edit]
References[edit]
- ^ Ito Y, Habuchi O (November 2000). "Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage". The Journal of Biological Chemistry. 275 (44): 34728–36. doi:10.1074/jbc.M909633199. PMID 10871629.
- ^ Ohtake S, Ito Y, Fukuta M, Habuchi O (November 2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". The Journal of Biological Chemistry. 276 (47): 43894–900. doi:10.1074/jbc.M104922200. PMID 11572857.
External links[edit]
- N-acetylgalactosamine+4-sulfate+6-O-sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
