Hepatitis C virus nonstructural protein 3

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HCV genome

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease.[1][2] C-terminal two-thirds of the protein also acts as helicase and nucleoside triphosphatase.[3] First (N-terminal) 180 aminoacids of NS3 has additional role as cofactor domains for NS2 protein.[4]

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  1. ^ Hijikata, M.; et al. (1993). "Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus". Proc. Natl. Acad. Sci. USA. 90 (22): 10773–10777. Bibcode:1993PNAS...9010773H. doi:10.1073/pnas.90.22.10773. PMC 47860. PMID 7504283.
  2. ^ Raney, Kevin D.; Sharma, Suresh D.; Moustafa, Ibrahim M.; Cameron, Craig E. (2010). "Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target". Journal of Biological Chemistry. 285 (30): 22725–22731. doi:10.1074/jbc.R110.125294. PMC 2906261. PMID 20457607.
  3. ^ Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase / J. Virol. July 2005 vol. 79 no. 14 8687-8697
  4. ^ Schregel, V; Jacobi, S; Penin, F; Tautz, N (2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proc Natl Acad Sci U S A. 106 (13): 5342–7. Bibcode:2009PNAS..106.5342S. doi:10.1073/pnas.0810950106. PMC 2663979. PMID 19282477.
  5. ^ "NS3/4A Protease Inhibitors - DrugBank".

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