CD7

CD7
Identifiers
Aliases	CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDs	OMIM: 186820 MGI: 88344 HomoloGene: 4471 GeneCards: CD7
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,317,608 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,930,244 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; appendix; ; lymph node; ; thymus; ; upper lobe of left lung; ; bone marrow cells; ; right lung; ; right lobe of liver; ; duodenum;
	Top expressed in
	blood; ; secondary oocyte; ; duodenum; ; thymus; ; spleen; ; morula; ; jejunum; ; intestinal villus; ; bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	adaptive immune response; T cell activation; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	924
	12516
	ENSG00000173762
	ENSMUSG00000025163
	P09564
	P50283
	NM_006137
	NM_009854
	NP_006128
	NP_033984
	Wikidata
View/Edit Human	View/Edit Mouse

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.^[5]

Function[edit]

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.^[5]

Interactions[edit]

CD7 has been shown to interact with PIK3R1.^[6]^[7]

Clinical significance[edit]

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.^[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173762 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025163 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD7 CD7 molecule".
^ Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
^ Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831. S2CID 26388891.
^ Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. doi:10.1016/j.leukres.2012.05.006. PMID 22682984.
^ Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541. S2CID 40541131.

Further reading[edit]

Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation". Immunologic Research. 24 (1): 31–52. doi:10.1385/IR:24:1:31. PMID 11485208. S2CID 23446615.
Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization". Immunogenetics. 31 (5–6): 412–3. doi:10.1007/BF02115022. PMID 1695199. S2CID 2959698.
Schanberg LE, Fleenor DE, Kurtzberg J, Haynes BF, Kaufman RE (January 1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene". Proceedings of the National Academy of Sciences of the United States of America. 88 (2): 603–7. Bibcode:1991PNAS...88..603S. doi:10.1073/pnas.88.2.603. PMC 50860. PMID 1703303.
Yoshikawa K, Seto M, Ueda R, Obata Y, Notake K, Yokochi T, Takahashi T (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7". Immunogenetics. 33 (5–6): 352–60. doi:10.1007/BF00216694. PMID 1711009. S2CID 20322510.
Ware RE, Scearce RM, Dietz MA, Starmer CF, Palker TJ, Haynes BF (December 1989). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule". Journal of Immunology. 143 (11): 3632–40. doi:10.4049/jimmunol.143.11.3632. PMID 2479685.
Osada S, Utsumi KR, Ueda R, Akao Y, Tsuge I, Nishida K, Okada J, Matsuoka H, Takahashi T (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17". Cytogenetics and Cell Genetics. 47 (1–2): 8–10. doi:10.1159/000132494. PMID 3258561.
Aruffo A, Seed B (November 1987). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system". The EMBO Journal. 6 (11): 3313–6. doi:10.1002/j.1460-2075.1987.tb02651.x. PMC 553785. PMID 3501369.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Lee DM, Schanberg LE, Fleenor DE, Seldin MF, Haynes BF, Kaufman RE (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters". Immunogenetics. 44 (2): 108–14. doi:10.1007/s002510050097. PMID 8662072. S2CID 29837811.
Bevec T, Stoka V, Pungercic G, Dolenc I, Turk V (April 1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L". The Journal of Experimental Medicine. 183 (4): 1331–8. doi:10.1084/jem.183.4.1331. PMC 2192513. PMID 8666891.
Leta E, Hou Z, Lederman L, Jung LK (October 1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7". Cellular Immunology. 173 (1): 15–21. doi:10.1006/cimm.1996.0247. PMID 8871597.
Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Slentz-Kesler KA, Hale LP, Kaufman RE (February 1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics. 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.
Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
Pace KE, Lee C, Stewart PL, Baum LG (October 1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1". Journal of Immunology. 163 (7): 3801–11. doi:10.4049/jimmunol.163.7.3801. PMID 10490978.
Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC (February 2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". The Journal of Biological Chemistry. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
Rossi MI, Yokota T, Medina KL, Garrett KP, Comp PC, Schipul AH, Kincade PW (January 2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes". Blood. 101 (2): 576–84. doi:10.1182/blood-2002-03-0896. PMID 12393702.

External links[edit]

CD7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD7 genome location and CD7 gene details page in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173762 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025163 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD7 CD7 molecule".

[pmid8918688-6] Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.

[pmid12594831-7] Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831. S2CID 26388891.

[Ogata_2012-8] Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. doi:10.1016/j.leukres.2012.05.006. PMID 22682984.

[pmid12374541-9] Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541. S2CID 40541131.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD7

Function[edit]

See also[edit]

Interactions[edit]

Clinical significance[edit]

References[edit]

Further reading[edit]

External links[edit]

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