Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
In melanocytic cells CEACAM1 gene expression may be regulated by MITF.
Kuroki M, Arakawa F, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y (April 1991). "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library". Biochemical and Biophysical Research Communications. 176 (2): 578–85. doi:10.1016/S0006-291X(05)80223-2. PMID2025273.
Frängsmyr L, Baranov V, Prall F, Yeung MM, Wagener C, Hammarström S (July 1995). "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa". Cancer Research. 55 (14): 2963–7. PMID7606710.
Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI (July 1995). "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase". Biochemistry. 34 (29): 9341–9. doi:10.1021/bi00029a009. PMID7626603.
Nédellec P, Turbide C, Beauchemin N (July 1995). "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene". European Journal of Biochemistry / FEBS. 231 (1): 104–14. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID7628460.
Hauck W, Nédellec P, Turbide C, Stanners CP, Barnett TR, Beauchemin N (July 1994). "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas". European Journal of Biochemistry / FEBS. 223 (2): 529–41. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID8055923.
Feuk-Lagerstedt E, Jordan ET, Leffler H, Dahlgren C, Karlsson A (November 1999). "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils". Journal of Immunology. 163 (10): 5592–8. PMID10553088.
Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L (August 2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clinical Cancer Research. 6 (8): 2988–93. PMID10955775.