Protein-coding gene in the species Homo sapiens
DIDO1 Identifiers Aliases DIDO1 External IDs OMIM : 604140 ; MGI : 1344352 ; HomoloGene : 34139 ; GeneCards : DIDO1 ; OMA :DIDO1 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in buccal mucosa cell sural nerve right uterine tube tendon of biceps brachii body of uterus Achilles tendon olfactory zone of nasal mucosa left ovary popliteal artery tibial arteries
Top expressed in Paneth cell Rostral migratory stream atrioventricular valve maxillary prominence mandibular prominence ciliary body epithelium of lens medullary collecting duct primitive streak retinal pigment epithelium
More reference expression data
BioGPS
Wikidata
Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene .[ 5] [ 6]
Apoptosis , a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000101191 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038914 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development" . Proc Natl Acad Sci U S A . 96 (14): 7992–7. Bibcode :1999PNAS...96.7992G . doi :10.1073/pnas.96.14.7992 PMC 22175 PMID 10393935 . ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1" . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 4 (2): 141–50. doi :10.1093/dnares/4.2.141 PMID 9205841 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Gomes I, Sharma TT, Edassery S, et al. (2002). "Novel transcription factors in human CD34 antigen-positive hematopoietic cells" . Blood . 100 (1): 107–19. doi :10.1182/blood.V100.1.107 PMID 12070015 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics . 84 (1): 205–10. doi :10.1016/j.ygeno.2004.01.011 . PMID 15203218 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Fütterer A, Campanero MR, Leonardo E, et al. (2005). "Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms" . J. Clin. Invest . 115 (9): 2351–62. doi :10.1172/JCI24177 . PMC 1190370 PMID 16127461 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Trachana V, van Wely KH, Guerrero AA, et al. (2007). "Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability" . Proc. Natl. Acad. Sci. U.S.A . 104 (8): 2691–6. Bibcode :2007PNAS..104.2691T . doi :10.1073/pnas.0611132104 PMC 1815243 PMID 17299043 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
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