Swine acute diarrhea syndrome coronavirus

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Swine acute diarrhea syndrome coronavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Alphacoronavirus
Subgenus: Rhinacovirus
Swine acute diarrhea syndrome coronavirus

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a coronavirus related to Rhinolophus bat coronavirus HKU2. It is transmitted through the feces of horseshoe bats to pigs. Piglets less than 5 days old die with a probability of up to 90%.[1]

The first outbreak appeared in 2017,[2] where it caused the death of more than 24,000 piglets on 4 farms. In 2018 and 2019, the virus re-emerged in China, but there were not large-scale losses.[2] This weak re-emergence is curious, and is reminiscent of how SARS emerged in 2003 and then disappeared.[2]

During in vitro testing, human and monkey cell lines exposed to SADS-CoV became infected, suggesting that SADS-CoV may pose a risk to human health.[2]

The SADS-CoV sampled from one of the first infected pig farms was found to be 95% genetically identical to one collected from horseshoe bats (Rhinolophus), "indicating the bat origin of the pig virus".[1]


  1. ^ a b Cui, Jie; Li, Fang; Shi, Zheng-Li (2018-12-10). "Origin and evolution of pathogenic coronaviruses". Nature Reviews. Microbiology. 17 (3): 181–192. doi:10.1038/s41579-018-0118-9. ISSN 1740-1526. PMC 7097006. PMID 30531947.
  2. ^ a b c d Yang, Yong-Le; Yu, Jia-Qi; Huang, Yao-Wei (2020-05-16). "Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery". Virus Research. 285: 198024. doi:10.1016/j.virusres.2020.198024. ISSN 0168-1702. PMC 7229464. PMID 32482591.